Keratin 18 (KRT18) antibody (Biotin)

Details for Product No. ABIN111181
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Antigen
Synonyms K18, CK18, Krt1-18, CYK18, cb83, dapk1, DreK18, sb:cb83, wu:fa13f02, wu:fb36b04, krt18, MGC64569, MGC75922, KRT18
Reactivity
Trout, Cow (Bovine), Dog (Canine), Hamster, Human, Mouse (Murine), Pig (Porcine), Rat (Rattus), Sheep (Ovine)
(416), (113), (107), (41), (36), (34), (28), (12), (12), (6), (6), (5), (4), (4), (4), (4), (3), (2), (2), (1), (1)
Host
Mouse
(252), (209), (9), (3), (2), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Biotin
(33), (27), (6), (5), (5), (5), (5), (5), (5), (5), (5), (1), (1)
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), ELISA, Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(327), (209), (141), (128), (108), (102), (91), (69), (50), (49), (9), (1), (1), (1), (1), (1), (1)
Pubmed 8 references available
Catalog no. ABIN111181
Quantity 0.25 mL
Price
478.50 $   Plus shipping costs $45.00
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Immunogen Cytokeratin 18 of molecular weight 45kDa. Purified from a HeLa cytoskeletal preparation.
Clone Ks18-04
Isotype IgG1
Specificity This Monoclonal antibody Ks 18.04 represents an excellent marker to discriminate simple epithelia from those of different origin. Tumors Specifically Detected: all adenocarcinoma, mammary carcinoma, urinary bladder carcinoma, undifferentiated carcinoma, cervix carcinoma, hepatocellular carcinoma. Polypeptide Reacting: Mr 45 000 polypeptide (Human keratin K18, formerly also designated cytokeratin 18) of all simple type epithelia and basal cells of many squamous, nonepidermal epithelia. Tested Reactivities on Cultured Cell Lines: HeLa and MCF-7.
Purification Affinity Chromatography on Protein A
Alternative Name Cytokeratin 18
Background Cytokeratin 18 is an acidic keratin which is found primarily in non squamous epithelia and is present in a majority of adenocarcinomas and ductal carcinomas but not in squamous cell carcinomas. Cytokeratin 18 exists in combination with Cytokeratin 8, a basic keratin. Hepatocellular carcinomas have been reportedly defined by the use of antibodies that recognize only Cytokeratins 8 and 18.
Alternate names: CK18, CYK18, Cell proliferation-inducing gene 46 protein, Cytokeratin-18, K18, KRT18, Keratin 18, Keratin type I cytoskeletal 18, Keratin-18
Gene ID 3875
NCBI Accession NP_000215.1
UniProt P05783
Research Area Signaling, Cytoskeleton, Extracellular Matrix
Application Notes Immunohistochemistry on frozen and paraffin sections. ELISA. Immunoblotting. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer 0.09% Sodium Azide
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Product cited in: Hantel, Lewrick, Schneider et al.: "Anti insulin-like growth factor I receptor immunoliposomes: a single formulation combining two anticancer treatments with enhanced therapeutic efficiency." in: The Journal of clinical endocrinology and metabolism, Vol. 95, Issue 2, pp. 943-52, 2010 (PubMed).

Background publications Bártek, Vojtĕsek, Stasková et al.: "A series of 14 new monoclonal antibodies to keratins: characterization and value in diagnostic histopathology." in: The Journal of pathology, Vol. 164, Issue 3, pp. 215-24, 1991 (PubMed).

Lauerová, Kovarik, Bártek et al.: "Novel monoclonal antibodies defining epitope of human cytokeratin 18 molecule." in: Hybridoma, Vol. 7, Issue 5, pp. 495-504, 1989 (PubMed).

Moll, Franke, Schiller et al.: "The catalog of human cytokeratins: patterns of expression in normal epithelia, tumors and cultured cells." in: Cell, Vol. 31, Issue 1, pp. 11-24, 1983 (PubMed).

Gomi, Yokoyama, Fujimoto et al.: "Mice devoid of the glial fibrillary acidic protein develop normally and are susceptible to scrapie prions." in: Neuron, Vol. 14, Issue 1, pp. 29-41, 1995 (PubMed).

Bantel, Ruck, Gregor et al.: "Detection of elevated caspase activation and early apoptosis in liver diseases." in: European journal of cell biology, Vol. 80, Issue 3, pp. 230-9, 2001 (PubMed).

Stumptner, Fuchsbichler, Heid et al.: "Mallory body--a disease-associated type of sequestosome." in: Hepatology (Baltimore, Md.), Vol. 35, Issue 5, pp. 1053-62, 2002 (PubMed).

Ikenouchi, Matsuda, Furuse et al.: "Regulation of tight junctions during the epithelium-mesenchyme transition: direct repression of the gene expression of claudins/occludin by Snail." in: Journal of cell science, Vol. 116, Issue Pt 10, pp. 1959-67, 2003 (PubMed).

Hosts (252), (209), (9), (3), (2), (1)
Reactivities (416), (113), (107), (41), (36), (34), (28), (12), (12), (6), (6), (5), (4), (4), (4), (4), (3), (2), (2), (1), (1)
Applications (327), (209), (141), (128), (108), (102), (91), (69), (50), (49), (9), (1), (1), (1), (1), (1), (1)
Conjugates (33), (27), (6), (5), (5), (5), (5), (5), (5), (5), (5), (1), (1)
Epitopes (29), (17), (17), (12), (12), (7), (6), (6), (4), (3), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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