CD2 Molecule (CD2) antibody

Details for Product No. ABIN111244
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Antigen
Reactivity
Human
(268), (109), (60), (15), (12), (10), (9), (7), (3), (1)
Host
Mouse
(282), (80), (63)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(55), (47), (39), (14), (11), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Functional Studies (Func), Flow Cytometry (FACS)
(293), (72), (72), (69), (61), (37), (23), (20), (14), (13), (10), (9), (4), (2), (2), (2), (1), (1), (1)
Pubmed 5 references available
Quantity 0.2 mg
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Catalog No. ABIN111244
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Immunogen Thymocytes.
Clone 6F10-3
Isotype IgG1
Specificity CD2 is a group of antibodies which recognizes the T cell receptor for sheep red blood cells. The antibody 6F10.3 reacts with the T11-2 epitope. The clone 39C1.5 reacts with the T11-1 epitope. The Combination of the monoclonal antibodies is strongly mitogenic in the presence of TPA.
Purification Protein A Sepharose Chromatography.
Alternative Name CD2
Background CD2 is a surface antigen of the human T lymphocyte lineage that is expressed on all peripheral blood T cells. It is one of the earliest T cell markers, being present on more than 95% of thymocytes, it is also found on some natural killer cells but not on B lymphocytes. CD2 interacts with lymphocyte function associated antigen (LFA3) and CD48/BCM1 to mediate adhesion between T cells and other cell types. CD2 is implicated in the triggering of T cells, the cytoplasmic domain is implicated in the signaling function. It is useful for the identification of lymphomas and leukaemias of T cell origin.
Alternate names: Erythrocyte receptor, LFA-2, LFA-3 receptor, Rosette receptor, SRBC, T-cell surface antigen CD2, T-cell surface antigen T11/Leu-5
Gene ID 9606
UniProt P06729
Research Area Stem Cells, Hematopoietic Progenitors, Hematopoietic Stem Cells, Adaptive Immunity, CD Antigens, Surface Receptors of Immune Cells
Application Notes Study of T Cell Functions. Fluorescence Microscopy or Flow Cytometry: 2 µg/5x10e5 cells/test. Immunohistochemistry (1/25-1/50): This antibody is only suitable on cryostat sections orcell smears. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Restore with 1 mL of distilled water.
Concentration 0.2 mg/mL (prior to lyophilization)
Buffer PBS containing 1 mg/ml BSA as stabilizer and without preservatives.
Preservative Without preservative
Storage 4 °C
Storage Comment Store at 2 - 8 °C. Do not freeze!
Expiry Date 12 months
Background publications Olive, Ragueneau, Cerdan et al.: "Anti-CD2 (sheep red blood cell receptor) monoclonal antibodies and T cell activation. I. Pairs of anti-T11.1 and T11.2 (CD2 subgroups) are strongly mitogenic for T cells in presence of 12-O-tetradecanoylphorbol 13-acetate." in: European journal of immunology, Vol. 16, Issue 9, pp. 1063-8, 1986 (PubMed).

Breitmeyer, Daley, Levine et al.: "The T11 (CD2) molecule is functionally linked to the T3/Ti T cell receptor in the majority of T cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 139, Issue 9, pp. 2899-905, 1987 (PubMed).

Huet, Boumsell, Raynal et al.: "Role in T-cell activation for HLA class I molecules from accessory cells: further distinction between activation signals delivered to T cells via CD2 and CD3 molecules." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 84, Issue 20, pp. 7222-6, 1987 (PubMed).

Sewell, Brown, Dunne et al.: "Molecular cloning of the human T-lymphocyte surface CD2 (T11) antigen." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 83, Issue 22, pp. 8718-22, 1986 (PubMed).

Meuer, Hussey, Fabbi et al.: "An alternative pathway of T-cell activation: a functional role for the 50 kd T11 sheep erythrocyte receptor protein." in: Cell, Vol. 36, Issue 4, pp. 897-906, 1984 (PubMed).

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