CD2 Molecule (CD2) antibody

Details for Product No. ABIN111249
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Antigen
Synonyms CD2, LFA-2, Ly-37, Ly37, SRBC, T11, CD2R, LFA2, OX-34, OX34
Reactivity
Human
(271), (113), (60), (15), (12), (10), (8), (7), (3), (1)
Host
Rat
(284), (83), (64)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(58), (54), (50), (11), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Flow Cytometry (FACS), Functional Studies (Func)
(292), (69), (69), (68), (64), (38), (23), (20), (14), (13), (10), (10), (10), (4), (2), (2), (2), (2), (1), (1)
Pubmed 7 references available
Quantity 0.2 mg
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Catalog No. ABIN111249
522.50 $
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Immunogen Human PHA-stimulated lymphocytic blasts.
Clone 39C1-5
Isotype IgG2a
Purification Ion Exchange Chromatography.
Alternative Name CD2
Background CD2 is a surface antigen of the human T lymphocyte lineage that is expressed on all peripheral blood T cells. It is one of the earliest T cell markers, being present on more than 95 % of thymocytes, it is also found on some natural killer cells but not on B lymphocytes. CD2 interacts with lymphocyte function associated antigen (LFA3) and CD48/BCM1 to mediate adhesion between T cells and other cell types. CD2 is implicated in the triggering of T cells, the cytoplasmic domain is implicated in the signaling function. It is useful for the identification of lymphomas and leukaemias of T cell origin.Synonyms: Erythrocyte receptor, LFA-2, LFA-3 receptor, Rosette receptor, SRBC, T-cell surface antigen CD2, T-cell surface antigen T11/Leu-5
Gene ID 9606
UniProt P06729
Research Area Stem Cells, Hematopoietic Progenitors, Hematopoietic Stem Cells, Adaptive Immunity, CD Antigens, Surface Receptors of Immune Cells
Application Notes Identification of T cells: Characterization of tumoral subsets in Leukemia, T Lymphoma andSezary syndrome Study of T cell functions. Fluorescence Microscopy or Flow Cytometry (2 μg/5x10e5 cells/test). Immunohistochemistry (1/25-1/50): This antibody is only suitable on cryostat sections orcell smears.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Reconstitution Restore with 1 mL of distilled water.
Concentration 0.2 mg/mL (prior to lyophilization)
Buffer PBS containing 1 mg/mL BSA as stabilizer and no preservative.
Preservative Without preservative
Handling Advice This product is photosensitive and should be protected from light
Storage 4 °C
Storage Comment Store at 2 - 8 °C. DO NOT FREEZE.
Background publications Dengler, Hoffmann, Knolle et al.: "Structural and functional epitopes of the human adhesion receptor CD58 (LFA-3)." in: European journal of immunology, Vol. 22, Issue 11, pp. 2809-17, 1992 (PubMed).

Olive, Ragueneau, Cerdan et al.: "Anti-CD2 (sheep red blood cell receptor) monoclonal antibodies and T cell activation. I. Pairs of anti-T11.1 and T11.2 (CD2 subgroups) are strongly mitogenic for T cells in presence of 12-O-tetradecanoylphorbol 13-acetate." in: European journal of immunology, Vol. 16, Issue 9, pp. 1063-8, 1986 (PubMed).

Denning, Dustin, Springer et al.: "Purified lymphocyte function-associated antigen-3 (LFA-3) activates human thymocytes via the CD2 pathway." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 141, Issue 9, pp. 2980-5, 1988 (PubMed).

Dustin, Sanders, Shaw et al.: "Purified lymphocyte function-associated antigen 3 binds to CD2 and mediates T lymphocyte adhesion." in: The Journal of experimental medicine, Vol. 165, Issue 3, pp. 677-92, 1987 (PubMed).

Sewell, Brown, Dunne et al.: "Molecular cloning of the human T-lymphocyte surface CD2 (T11) antigen." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 83, Issue 22, pp. 8718-22, 1986 (PubMed).

Meuer, Hussey, Fabbi et al.: "An alternative pathway of T-cell activation: a functional role for the 50 kd T11 sheep erythrocyte receptor protein." in: Cell, Vol. 36, Issue 4, pp. 897-906, 1984 (PubMed).

General Breitmeyer, Daley, Levine et al.: "The T11 (CD2) molecule is functionally linked to the T3/Ti T cell receptor in the majority of T cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 139, Issue 9, pp. 2899-905, 1987 (PubMed).

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