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CD80 (CD80) antibody

Details for Product No. ABIN111250
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Antigen
Synonyms CD8, Leu2, MAL, p32, B71, Cd28l, Ly-53, Ly53, MIC17, TSA1, B7, B7-1, B7.1, BB1, CD28LG, CD28LG1, LAB7
Reactivity
Human
(189), (152), (32), (4), (4), (3), (2), (1)
Host
Mouse
(160), (75), (73), (51), (6), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(40), (39), (36), (14), (6), (6), (5), (4), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (1), (1), (1), (1)
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Functional Studies (Func), Flow Cytometry (FACS)
(236), (94), (72), (53), (30), (28), (24), (23), (20), (18), (8), (2), (2), (2), (1), (1), (1)
Pubmed 6 references available
Quantity 0.2 mg
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
Catalog No. ABIN111250
654.50 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen Jijoye cells (Human Burkitt Lymphoma cell line)
Clone MAB104
Isotype IgG1
Specificity The antibody reacts with in vitro activated normal B cells. Reacts weakly with a small proportion of non-activated normal B cells. Does not react with peripheral monocytes, resting and activated normal T cells, T-cell lines and T-cell clones.
Purification Protein A affinity chromatography
Alternative Name CD80
Background CD80 is a member of the Ig superfamily and serves as the ligand for two T cell molecules, CD28 and CTLA4. Interactions between CD28 and CD80 on activated B cells result in enhanced T cell activation. CD80 is rapidly induced on the surface of in vitro activated B cells, Epstein Barr Virus (EBV) transformed B cell lines, Burkitts lymphoma cell lines, freshly isolated follicular B lymphoma cells, T cells, and monocytes. It is also expressed at high levels in dendritic cells. It reacts weakly with a small proportion of non activated normal B cells and with HTLV1 infected T cells. CD80 does not react with peripheral monocytes, resting and activated normal T cells, T cell lines and T cell clones, nor with myelomonocytic cell lines.
Alternate names: Activation B7-1 antigen, B7-1, B7.1, BB1, CD28LG, CD28LG1, CTLA-4 counter-receptor B7.1, LAB7, T-lymphocyte activation antigen CD80
Gene ID 941
NCBI Accession NP_005182.1
UniProt P33681
Research Area Stem Cells, Hematopoietic Progenitors, Adaptive Immunity, CD Antigens, Surface Receptors of Immune Cells
Application Notes Flow cytometry. Functional study of B cell subpopulations. Fluorescence microscopy or flow cytometry (2 g/5x10e5 cells/test). Immunohistochemistry (1: 20 to 1: 50, suitable on frozen sections or cell smears). Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Restore with 1.0 mL of distilled water.
Concentration 0.2 mg/mL (prior to lyophilization)
Buffer PBS containing 1.0 mg/ml BSA
Preservative Azide free
Storage 4 °C
Storage Comment Store at 2 - 8 °C.
Expiry Date 12 months
Background publications Vallé, Aubry, Durand et al.: "IL-4 and IL-2 upregulate the expression of antigen B7, the B cell counterstructure to T cell CD28: an amplification mechanism for T-B cell interactions." in: International immunology, Vol. 3, Issue 3, pp. 229-35, 1991 (PubMed).

Vallé, Garrone, Yssel et al.: "mAb 104, a new monoclonal antibody, recognizes the B7 antigen that is expressed on activated B cells and HTLV-1-transformed T cells." in: Immunology, Vol. 69, Issue 4, pp. 531-5, 1990 (PubMed).

General June, Ledbetter, Linsley et al.: "Role of the CD28 receptor in T-cell activation." in: Immunology today, Vol. 11, Issue 6, pp. 211-6, 1990 (PubMed).

Linsley, Clark, Ledbetter: "T-cell antigen CD28 mediates adhesion with B cells by interacting with activation antigen B7/BB-1." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 87, Issue 13, pp. 5031-5, 1990 (PubMed).

Freeman, Freedman, Segil et al.: "B7, a new member of the Ig superfamily with unique expression on activated and neoplastic B cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 143, Issue 8, pp. 2714-22, 1989 (PubMed).

Freedman, Freeman, Horowitz et al.: "B7, a B-cell-restricted antigen that identifies preactivated B cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 139, Issue 10, pp. 3260-7, 1987 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN111250
654.50 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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