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Cadherin 5 (CDH5) antibody

Antigen

Cadherin 5 (CDH5)
Synonyms UVO, CDHE, ECAD, LCAM, Arc-1, CD324, 7B4, Vec, Cd144, VE-Cad, AA408225, VECAD2, VE-cadherin-2, Pcdh14, VE-cad-2, CDH5, wu:fc88a07
Clonality Monoclonal (TEA1-31)
Host
Alternatives

Mouse
Reactivity
Alternatives

Human
Conjugate
Alternatives Un-conjugated
Application
Alternatives Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunoprecipitation (IP)
5 references available
Catalog no. ABIN111252
Quantity 0.2 mg
Price 550.00 $   Plus shipping costs $45.00
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Additional Information
Application Details Publications Alternatives back to top

Alternative name CD144 / Cadherin-5
UniProt P33151
Immunogen Human endothelial cells (HUVEC)
Cross-Reactivity Human
Isotype IgG1
Clone TEA1-31
Description Cadherins are calcium dependent cell adhesion proteins. They preferentially interact withthemselves in a homophilic manner in connecting cells, cadherins may thus contribute tothe sorting of heterogeneous cell types. This cadherin may play an important role inendothelial cell biology through control of the cohesion and organization of theintercellular junctions. It associates with alpha catenin forming a link to the cytoskeleton.
Characteristics Synonyms: VE-Cadherin, Vascular endothelial cadherin, CDH5, 7B4 antigen

Application Details
Publications Alternatives back to top

Application Notes Suitable for use in Immunoprecipitation. Immunofluorescence: Working dilution on frozen sections 25-50 ug/ml. Incubation: 1 hour at 37C. Immunoelectroncytochemistry: Working dilution on ultra thin frozen sections: 25-50 ug/ml. Incubation overnight in a humid chamber at 2-8C. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Buffer PBS with 1 mg/ml BSA, containing no preservativeReconstitution: Restore with 1 ml of distilled water
Preservative Azide Free
Storage Store the reconstituted antibody at 2-8°C for one month (add 0. 09% Sodium Azide) or at-20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
Research Area CD Antigens, Surface Receptors of Immune Cells, Extracellular Matrix, Signaling, Cytoskeleton
Restrictions For Research Use only

Publications
Application Details Alternatives back to top

Magee, Buxton: "Transmembrane molecular assemblies regulated by the greater cadherin family." in: Current opinion in cell biology, Vol. 3, Issue 5, pp. 854-61, 1991 (PubMed).

Takeichi: "Cadherin cell adhesion receptors as a morphogenetic regulator." in: Science (New York, N.Y.), Vol. 251, Issue 5000, pp. 1451-5, 1991 (PubMed).

Takeichi: "Cadherins: a molecular family important in selective cell-cell adhesion." in: Annual review of biochemistry, Vol. 59, pp. 237-52, 1990 (PubMed).

Leach, Clark, Lampugnani et al.: "Immunoelectron characterisation of the inter-endothelial junctions of human term placenta." in: Journal of cell science, Vol. 104 ( Pt 4), pp. 1073-81, 1993 (PubMed).

Fukudome, Yanagihara, Takeichi et al.: "Characterization of a mutant E-cadherin protein encoded by a mutant gene frequently seen in diffuse-type human gastric carcinoma." in: International journal of cancer. Journal international du cancer, Vol. 88, Issue 4, pp. 579-83, 2000 (PubMed).