CD56 antibody (Neural Cell Adhesion Molecule 1) (PE)

Details for Product anti-NCAM1 Antibody No. ABIN111266, Supplier: Log in to see
Antigen
  • NCAM1
  • ncam
  • n-cam
  • CD56
  • MSK39
  • NCAM
  • E-NCAM
  • NCAM-1
  • Ncam
  • Cd56
  • N-CAM
  • N-CAM-1
  • NCAM-C
  • NCAMC
  • fj56g09
  • ncam1
  • wu:fj56g09
  • neural cell adhesion molecule 1
  • neural cell adhesion molecule 1a
  • NCAM1
  • ncam1
  • LOC100348118
  • ncam1-a
  • Ncam1
  • ncam1a
Reactivity
Human, Primate
900
179
175
53
23
22
16
8
6
5
4
4
3
2
2
1
Host
Mouse
782
128
25
13
Clonality (Clone)
Monoclonal ()
Conjugate
This CD56 antibody is conjugated to PE
74
62
49
27
27
26
26
24
19
18
18
13
13
13
13
12
12
12
8
8
8
7
7
6
6
5
4
4
4
4
4
3
2
2
2
2
2
2
2
2
2
Application
Flow Cytometry (FACS)
554
387
293
189
181
180
171
139
138
26
17
6
5
5
4
4
3
3
2
2
2
2
2
1
1
1
1
1
1
1
Options
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Immunogen KG-1 human acute myelogenous leukemia cell line
Clone MEM-188
Isotype IgG2a
Specificity The antibody MEM-188 reacts with a 180 kDa isoform of CD56 (NCAM) expressed in leukocytes. It has been suggested that the antibody MEM-188 could react with rhesus monkey lymphocytes. Reactivity with other NCAM isoforms has not been tested.
Alternative Name CD56 (NCAM1 Antibody Abstract)
Background CD56 (NCAM, neural cell adhesion molecule) is a transmembrane glycoprotein of immunoglobulin family serving as adhesive molecule which is ubiquitously expressed in nervous system, usually as 120 kDa, 140 kDa or 180 kDa isoform, and it is also found on T cells and NK cells. Polysialic modification results in reduction of CD56-mediated cell adhesion and is involved in cell migration, axonal growth, pathfinding and synaptic plasticity. CD56 is a widely used neuroendocrine marker with a high sensitivity for neuroendocrine tumours and ovarian granulosa cell tumours.Synonyms: N-CAM-1, NCAM, NCAM-1, Neural cell adhesion molecule 1
Gene ID 4684
NCBI Accession NP_000606
UniProt P13591
Research Area CD Antigens, Surface Receptors of Immune Cells, Signaling
Application Notes Flow Cytometry analysis of human blood cells using 20 l reagent / 100 mLof whole bloodor 10^6 cells in a suspension.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0.1 mg/mL
Buffer Phosphate buffered saline (PBS) containing 15 mM sodium azide and 0.2 % (w/v) high-grade protease free Bovine Serum Albumin (BSA) as a stabilizing agent.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Dilute only prior to immediate use
Storage 4 °C
Storage Comment Store the antibody (undiluted) at 2-8 °C. DO NOT FREEZE! Freezing alkaline phosphatase conjugates will result in a substantial loss of enzymatic activity.
Background publications Xu, Hao, Sun, Fang, Lu, Li, Zhao, Peng, Yan: "2:1 multiplexing function in a simple molecular system." in: Sensors (Basel, Switzerland), Vol. 12, Issue 4, pp. 4421-30, 2012 (PubMed).

Ohishi, Kaku, Oya, Kobayashi, Wake, Tsuneyoshi: "CD56 expression in ovarian granulosa cell tumors, and its diagnostic utility and pitfalls." in: Gynecologic oncology, Vol. 107, Issue 1, pp. 30-8, 2007 (PubMed).

McCluggage, McKenna, McBride: "CD56 is a sensitive and diagnostically useful immunohistochemical marker of ovarian sex cord-stromal tumors." in: International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists, Vol. 26, Issue 3, pp. 322-7, 2007 (PubMed).

Drbal, Moertelmaier, Holzhauser, Muhammad, Fuertbauer, Howorka, Hinterberger, Stockinger, Schütz: "Single-molecule microscopy reveals heterogeneous dynamics of lipid raft components upon TCR engagement." in: International immunology, Vol. 19, Issue 5, pp. 675-84, 2007 (PubMed).

Yates, Rovis, Mitchell, Afzali, Tsang, Garin, Lechler, Lombardi, Garden: "The maintenance of human CD4+ CD25+ regulatory T cell function: IL-2, IL-4, IL-7 and IL-15 preserve optimal suppressive potency in vitro." in: International immunology, Vol. 19, Issue 6, pp. 785-99, 2007 (PubMed).

Jakovcevski, Mo, Zecevic: "Down-regulation of the axonal polysialic acid-neural cell adhesion molecule expression coincides with the onset of myelination in the human fetal forebrain." in: Neuroscience, Vol. 149, Issue 2, pp. 328-37, 2007 (PubMed).

Lin, Liu, Chen, Wang, Medeiros, Hsu: "CD94 1A transcripts characterize lymphoblastic lymphoma/leukemia of immature natural killer cell origin with distinct clinical features." in: Blood, Vol. 106, Issue 10, pp. 3567-74, 2005 (PubMed).

Brdicková, Brdicka, Angelisová, Horváth, Spicka, Hilgert, Paces, Simeoni, Kliche, Merten, Schraven, Horejsí: "LIME: a new membrane Raft-associated adaptor protein involved in CD4 and CD8 coreceptor signaling." in: The Journal of experimental medicine, Vol. 198, Issue 10, pp. 1453-62, 2003 (PubMed).

Brdicka, Imrich, Angelisová, Brdicková, Horváth, Spicka, Hilgert, Lusková, Dráber, Novák, Engels, Wienands, Simeoni, Osterreicher, Aguado, Malissen, Schraven, Horejsí: "Non-T cell activation linker (NTAL): a transmembrane adaptor protein involved in immunoreceptor signaling." in: The Journal of experimental medicine, Vol. 196, Issue 12, pp. 1617-26, 2002 (PubMed).

Lanier, Chang, Azuma, Ruitenberg, Hemperly, Phillips: "Molecular and functional analysis of human natural killer cell-associated neural cell adhesion molecule (N-CAM/CD56)." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 146, Issue 12, pp. 4421-6, 1991 (PubMed).