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CD40 antibody

CD40 Reactivity: Human FACS, Func, IHC (p), IHC (fro) Host: Mouse Monoclonal MAB89 unconjugated
Catalog No. ABIN111321
  • Target See all CD40 Antibodies
    CD40
    Reactivity
    • 188
    • 97
    • 20
    • 20
    • 7
    • 6
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Human
    Host
    • 103
    • 100
    • 43
    • 3
    • 1
    • 1
    • 1
    Mouse
    Clonality
    • 156
    • 89
    • 5
    Monoclonal
    Conjugate
    • 119
    • 22
    • 20
    • 20
    • 12
    • 6
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CD40 antibody is un-conjugated
    Application
    • 145
    • 92
    • 62
    • 50
    • 30
    • 28
    • 19
    • 18
    • 17
    • 14
    • 13
    • 13
    • 5
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    • 1
    • 1
    Flow Cytometry (FACS), Functional Studies (Func), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Specificity
    CD40 B cells.
    Immunogen
    Anti-mu activated tonsillar human B cells.
    Clone
    MAB89
    Isotype
    IgG1
    Top Product
    Discover our top product CD40 Primary Antibody
  • Application Notes
    Fluorescent Microscopy or Flow Cytometry: 2 μg/5x10e5 cells/test. Activation assays: Working concentration: 10 ng/mL. Study of of B-cell proliferation, B-cell growth and activation factors. Functional Study of B-cell subpopulations.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Reconstitution
    Restore with 1 mL of distilled water.
    Concentration
    0.2 mg/mL (prior to lyophilization)
    Buffer
    PBS buffer containing 1 mg/mL BSA as stabilizer without preservatives.
    Preservative
    Without preservative
    Storage
    4 °C
    Storage Comment
    Store at 2 - 8 °C.
  • Target
    CD40
    Alternative Name
    CD40 (CD40 Products)
    Synonyms
    Bp50 antibody, CDW40 antibody, TNFRSF5 antibody, p50 antibody, AI326936 antibody, GP39 antibody, HIGM1 antibody, IGM antibody, IMD3 antibody, T-BAM antibody, TRAP antibody, Tnfrsf5 antibody, TNFSF5 antibody, CD40 molecule antibody, CD40 antigen antibody, CD40 antibody, Cd40 antibody
    Background
    CD40 is a 49 kDa type I integral membrane protein of the NGF receptor family. CD40 is found on normal and neoplastic B cells.(1) It is a pan-B marker, absent only from terminally differentiated plasma cells. CD40 is predicted to function in the process of B cell selection in the germinal center. Studies demonstrated that it induces strong homotypic adhesions in resting B cells and, together with Interleukin-4 (IL-4) maintains the cell cycle of B blasts and promotes the switch to IgE secretion. (1,2) Purified B cells cultured in the CD40 system in the presence of IL-10 differentiate into plasma cells and secrete large amounts of immunoglobulins. (3) The ligand for CD40 is a membrane glycoprotein on activated T cells that induces B cell proliferation and immunoglobulin secretion. (4) This clone acts in synergy with IL-4 to induce the increase of B-cell volume and the proliferation of anti IgM antibody-co-stimulated or pre-activated B cells. (5)Synonyms: B-cell surface antigen CD40, Bp50, CD40L receptor, CDw40, TNFRSF5, Tumor necrosis factor receptor superfamily member 5
    Gene ID
    958
    NCBI Accession
    NP_001241
    UniProt
    P25942
    Pathways
    NF-kappaB Signaling, Cellular Response to Molecule of Bacterial Origin, M Phase, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints
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