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ABI1 antibody (Abl-Interactor 1)

Details for Product anti-ABI1 Antibody No. ABIN111459, Supplier: Login to see New
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Antigen
Alternatives
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(95), (39), (37), (2), (1), (1)
Host
Mouse
(94), (3)
Clonality (Clone)
Monoclonal ()
Conjugate
This ABI1 antibody is un-conjugated
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA), Immunofluorescence (IF), Western Blotting (WB)
(68), (34), (22), (20), (12), (12), (12), (11), (8), (6), (2), (2)
Pubmed 7 references available
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Quantity 0.2 mL
Shipping to United States ( )
Availability
Immunogen Recombinant Hssh3bp1 (human spectrin SH3 domain binding protein 1)
Clone 4-00E-002
Isotype IgG2b
Specificity This antibody was developed against the spectrin SH3 domain binding protein Hssh3bp1 (3).
Purification Protein A Chromatography
Alternative Name ABI1 / SSH3BP1 (ABI1 Antibody Abstract)
Background Hssh3bp1 is a marker of macropinocytic vesicles and a potential regulator of macropinocytosis (2). The gene encoding Hssh3bp1 has a role as a tumor suppressor gene which is inactivated during prostate tumorigenesis (1).Synonyms: ABI1, Abelson interactor 1, Abi-1, Abl interactor 1, Abl-binding protein 4, AblBP4, Eps8 SH3 domain-binding protein, Nap1-binding protein, SSH3BP1, Spectrin SH3 domain-binding protein 1, e3B1
Gene ID 10006
NCBI Accession NP_001012768
UniProt Q8IZP0
Pathways RTK Signaling
Application Notes Western blot: 1/1,000-1/2,000. Immunofluorescence: 1/100-1/500. Immunohistochemistry: 1/40-1/100. Formalin-fixed, paraffin-embedded sections andfrozen sections. For optimal staining, sections should be pre-treated for antigenunmasking.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS without preservatives
Preservative Without preservative
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Background publications Swanson, Watts: "Macropinocytosis." in: Trends in cell biology, Vol. 5, Issue 11, pp. 424-8, 2004 (PubMed).

Macoska, Xu, Ziemnicka et al.: "Loss of expression of human spectrin src homology domain binding protein 1 is associated with 10p loss in human prostatic adenocarcinoma." in: Neoplasia (New York, N.Y.), Vol. 3, Issue 2, pp. 99-104, 2001 (PubMed).

Xu, Ziemnicka, Merz et al.: "Human spectrin Src homology 3 domain binding protein 1 regulates macropinocytosis in NIH 3T3 cells." in: Journal of cell science, Vol. 113 Pt 21, pp. 3805-14, 2000 (PubMed).

De Matteis, Morrow: "Spectrin tethers and mesh in the biosynthetic pathway." in: Journal of cell science, Vol. 113 ( Pt 13), pp. 2331-43, 2000 (PubMed).

Ziemnicka-Kotula, Xu, Gu et al.: "Identification of a candidate human spectrin Src homology 3 domain-binding protein suggests a general mechanism of association of tyrosine kinases with the spectrin-based membrane skeleton." in: The Journal of biological chemistry, Vol. 273, Issue 22, pp. 13681-92, 1998 (PubMed).

Bennett, Gilligan: "The spectrin-based membrane skeleton and micron-scale organization of the plasma membrane." in: Annual review of cell biology, Vol. 9, pp. 27-66, 1994 (PubMed).

Lamaze, Schmid: "The emergence of clathrin-independent pinocytic pathways." in: Current opinion in cell biology, Vol. 7, Issue 4, pp. 573-80, 1996 (PubMed).

Catalog No. ABIN111459

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