Spectrin Binding Protein antibody

Details for Product No. ABIN111459
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Human, Mouse (Murine), Rat (Rattus)
Clonality (Clone)
Monoclonal ()
Immunohistochemistry (Frozen Sections) (IHC (fro)), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blotting (WB)
(2), (2), (2), (1), (1)
Pubmed 7 references available
Quantity 0.2 mL
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Catalog No. ABIN111459
1,281.50 $
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Immunogen Recombinant Hssh3bp1 (human spectrin SH3 domain binding protein 1)
Clone 4E2
Isotype IgG2b
Specificity This antibody was developed against the spectrin SH3 domain binding protein Hssh3bp1 (3).
Purification Protein A Chromatography
Background Hssh3bp1 is a marker of macropinocytic vesicles and a potential regulator of macropinocytosis (2). The gene encoding Hssh3bp1 has a role as a tumor suppressor gene which is inactivated during prostate tumorigenesis (1).
Alternate names: ABI1, Abelson interactor 1, Abi-1, Abl interactor 1, Abl-binding protein 4, AblBP4, Eps8 SH3 domain-binding protein, Nap1-binding protein, SSH3BP1, Spectrin SH3 domain-binding protein 1, e3B1
Gene ID 10006
NCBI Accession NP_001012768
UniProt Q8IZP0
Application Notes Western blot: 1/1,000-1/2,000. Immunofluorescence: 1/100-1/500. Immunohistochemistry: 1/40-1/100. Formalin-fixed, paraffin-embedded sections andfrozen sections. For optimal staining, sections should be pre-treated for antigenunmasking. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS without preservatives
Preservative Without preservative
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Expiry Date 12 months
Background publications Lamaze, Schmid: "The emergence of clathrin-independent pinocytic pathways." in: Current opinion in cell biology, Vol. 7, Issue 4, pp. 573-80, 1996 (PubMed).

Bennett, Gilligan: "The spectrin-based membrane skeleton and micron-scale organization of the plasma membrane." in: Annual review of cell biology, Vol. 9, pp. 27-66, 1994 (PubMed).

Ziemnicka-Kotula, Xu, Gu et al.: "Identification of a candidate human spectrin Src homology 3 domain-binding protein suggests a general mechanism of association of tyrosine kinases with the spectrin-based membrane skeleton." in: The Journal of biological chemistry, Vol. 273, Issue 22, pp. 13681-92, 1998 (PubMed).

De Matteis, Morrow: "Spectrin tethers and mesh in the biosynthetic pathway." in: Journal of cell science, Vol. 113 ( Pt 13), pp. 2331-43, 2000 (PubMed).

Xu, Ziemnicka, Merz et al.: "Human spectrin Src homology 3 domain binding protein 1 regulates macropinocytosis in NIH 3T3 cells." in: Journal of cell science, Vol. 113 Pt 21, pp. 3805-14, 2000 (PubMed).

Macoska, Xu, Ziemnicka et al.: "Loss of expression of human spectrin src homology domain binding protein 1 is associated with 10p loss in human prostatic adenocarcinoma." in: Neoplasia (New York, N.Y.), Vol. 3, Issue 2, pp. 99-104, 2001 (PubMed).

Swanson, Watts: "Macropinocytosis." in: Trends in cell biology, Vol. 5, Issue 11, pp. 424-8, 2004 (PubMed).

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