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VZV / HHV-3 antibody

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Varicella Zoster Virus (VZV)
(3), (3), (2), (1)
Clonality (Clone)
Monoclonal ()
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF), Immunoprecipitation (IP)
(9), (6), (4), (3), (1), (1), (1), (1)
Pubmed 2 references available
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Quantity 0.5 mg
Shipping to United States ( )
Immunogen VZV Ellen Strain from VZV-infected monkey kidney cells (BSC-1).
Clone NCP-1
Isotype IgG1
Purification Protein G chromatography
Background Varicella Zoster Virus (VZV), a member of the human herpes virus family, causes two distinct clinical manifestations: childhood chickenpox(Varicella) and shingles (zoster). Varicella is the outcome of the primary infection with VZV, whereas, zoster is the result of VZV reactivation from latently infected sensory ganglia which occurs predominantly in aging and immunosuppressed individuals. VZV is closely related to the herpes simplex viruses (HSV), sharing much genome homology. The known envelope glycoproteins (gB, gC, gE, gH, gI, gK, gL) correspond with those in HSV, however there is no equivalent of HSV gD. VZV virons are spherical and 150-200 nm in diameter. Its lipid envelope encloses the nucleocapsid of 162 capsomeres arranged in a hexagonal form. Its DNA is a single linear, double strand molecule, 125,000 nt long.Synonyms: HHV3, Varizella zoster
Research Area Virology
Application Notes Intended for the detection of VZV nucleocapsid protein (NCP) in cell culture by indirectImmunofluorescent antibody technique and for Immunoprecipitation tests. Also works in Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer 20 mM Na2HPO4, pH 9.0, without preservatives and stabilizers.
Preservative Without preservative
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
General Drew, Mintz: "Rapid diagnosis of varicella-zoster virus infection by direct immunofluorescence." in: American journal of clinical pathology, Vol. 73, Issue 5, pp. 699-701, 1980 (PubMed).

Davison, Scott: "The complete DNA sequence of varicella-zoster virus." in: The Journal of general virology, Vol. 67 ( Pt 9), pp. 1759-816, 1986 (PubMed).

Catalog No. ABIN111513

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