VZV / HHV-3 antibody

Details for Product No. ABIN111514
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Antigen
Reactivity
Varicella Zoster Virus (VZV)
(6), (3), (1), (1)
Host
Mouse
(11)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(1)
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunoprecipitation (IP)
(11), (9), (8), (5), (4), (2), (1), (1)
Pubmed 2 references available
Quantity 0.5 mg
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Catalog No. ABIN111514
445.50 $
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Clone IE(62)
Isotype IgG1
Specificity Clone IE(62) reacts with VZV immediate early protein encoded by gene 62.
Purification Protein G chromatography.
Background Varicella Zoster Virus (VZV), a member of the human herpes virus family, causes two distinct clinical manifestations: childhood chickenpox(Varicella) and shingles (zoster). Varicella is the outcome of the primary infection with VZV, whereas, zoster is the result of VZV reactivation from latently infected sensory ganglia which occurs predominantly in aging and immunosuppressed individuals. VZV is closely related to the herpes simplex viruses (HSV), sharing much genome homology. The known envelope glycoproteins (gB, gC, gE, gH, gI, gK, gL) correspond with those in HSV, however there is no equivalent of HSV gD. VZV virons are spherical and 150-200 nm in diameter. Its lipid envelope encloses the nucleocapsid of 162 capsomeres arranged in a hexagonal form. Its DNA is a single linear, double strand molecule, 125,000 nt long.
Alternate names: HHV3, Varizella zoster
Gene ID 1487695
NCBI Accession NP_040184
UniProt P09310
Research Area Virology
Application Notes This monoclonal antibody is intended for the detection of VZV IE62 either by indirectImmunofluorescence or Immunoprecipitation test. Also works in Immunohistochemistry. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer 20 mM Na2HPO4, pH 9.0, without preservatives and stabilizers.
Preservative Without preservative
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Davison, Scott: "The complete DNA sequence of varicella-zoster virus." in: The Journal of general virology, Vol. 67 ( Pt 9), pp. 1759-816, 1986 (PubMed).

Drew, Mintz: "Rapid diagnosis of varicella-zoster virus infection by direct immunofluorescence." in: American journal of clinical pathology, Vol. 73, Issue 5, pp. 699-701, 1980 (PubMed).

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