AIF1 antibody (Allograft Inflammatory Factor 1) (Biotin)

Details for Product anti-AIF1 Antibody No. ABIN112010, Supplier: Log in to see
Antigen
  • fa04b11
  • wu:fa04b11
  • AIF1
  • aif1
  • AIF-1
  • IBA1
  • IRT-1
  • IRT1
  • Bart1
  • iba1
  • mrf-1
  • AI607846
  • D17H6S50E
  • G1
  • Iba1
  • AIF
  • AIF1L
  • allograft inflammatory factor 1
  • Allograft inflammatory factor 1
  • allograft inflammatory factor 1-like
  • aif1
  • AIF1
  • Aif1
  • LOC100350092
  • C9ORF58
Alternatives
anti-Human AIF1 antibody for Immunohistochemistry (Paraffin-embedded Sections)
Reactivity
Human, Rat (Rattus)
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107
97
8
7
2
2
1
1
Host
Mouse
142
56
36
2
1
Clonality (Clone)
Monoclonal ()
Conjugate
This AIF1 antibody is conjugated to Biotin
22
22
11
5
4
4
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
184
123
106
67
28
27
19
13
11
10
7
4
2
2
2
2
1
Options
Supplier
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Immunogen Purified Human recombinant AIF-1 Epitope is not further characterized.
Clone 1022-5
Isotype IgG2b
Specificity Recognizes AIF-1. This antibody BM4114B reacts with activated Macrophages / Microglial cells.
Purification Affinity Chromatography.
Alternative Name AIF1 (AIF1 Antibody Abstract)
Background Allograft Inflammatory Factor-1 is a Ca2+-binding peptide produced by activated macrophages and microglial cells. It has been suggested that AIF-1 expression is associated with chronic inflammatory processes. AIF-1, like the Ca2+-binding peptides MRP8 and MRP14, is expressed by activated macrophages and might participate in a variety of pathogenic processes in the mammalian brain and in chronic transplant rejection. It has been shown to be expressed early and persistently in chronically rejecting cardiac allografts but not in cardiac syngrafts and host hearts. The recently described apoptosis-inducing factor AIF is not related to AIF-1.Synonyms: AIF-1, Allograft inflammatory factor 1, IBA1, Ionized Calcium-Binding Adapter Molecule 1, Protein G1
Gene ID 199
NCBI Accession NP_001614
UniProt P55008
Research Area Inflammation
Pathways Smooth Muscle Cell Migration
Application Notes Immunohistochemistry on Paraffin Sections: 5 μg/mL (1/40). Pretreatment is not necessary. Suggested Positive Control: Human spleen. This antibody does not react on routinely processed Frozen Sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Reconstitution Restore by adding 0.5 mL distilled water.
Concentration 0.2 mg/mL
Buffer PBS containing 5 mg/mL BSA as a stabilizer and 0.09 % Sodium Azide as a preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice This product is photosensitive and should be protected from light
Storage 4 °C
Storage Comment Store the antibody undiluted Prior to and following reconstitution at 2-8 °C. DO NOT FREEZE!
Background publications Schluesener, Seid, Meyermann: "Effects of autoantigen and dexamethasone treatment on expression of endothelial-monocyte activating polypeptide II and allograft-inflammatory factor-1 by activated macrophages and microglial cells in lesions of experimental autoimmune encephalomyelitis, n" in: Acta neuropathologica, Vol. 97, Issue 2, pp. 119-26, 1999 (PubMed).

Schluesener, Seid, Kretzschmar, Meyermann: "Allograft-inflammatory factor-1 in rat experimental autoimmune encephalomyelitis, neuritis, and uveitis: expression by activated macrophages and microglial cells." in: Glia, Vol. 24, Issue 2, pp. 244-51, 1998 (PubMed).

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