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Transportin 1 antibody (TNPO1)

Details for Product anti-TNPO1 Antibody No. ABIN112070, Supplier: Login to see New
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Human, Monkey, Rabbit
(70), (33), (23), (6), (2), (2), (1)
(70), (10), (3)
Clonality (Clone)
Monoclonal ()
This Transportin 1 antibody is un-conjugated
(6), (6), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF), Immunoprecipitation (IP), Western Blotting (WB)
(59), (43), (24), (22), (20), (11), (10), (7), (6), (6), (2)
Pubmed 1 reference available
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Quantity 0.1 mL
Shipping to United States ( )
Immunogen Recombinant his tagged Transportin-1 (Human)
Clone D45
Isotype IgG1
Specificity Human Transportin-1. Detects a band of approximately 90 kDa.
Purification Protein A Chromatography
Alternative Name Transportin-1 (TNPO1) (TNPO1 Antibody Abstract)
Background Heterogeneous nuclear ribonucleoprotein HNRNPA1 is an abundant nuclear protein that plays an important role in pre-mRNA processing and mRNA export from the nucleus. A1 shuttles rapidly between the nucleus and the cytoplasm, and a 38-amino acid domain, M9, serves as the bi-directional transport signal of A1. Recently, a 90-kD protein, Transportin, was identified as the mediator of A1 nuclear import. Transportin mediates the nuclear import of additional HNRNP proteins, including HNRNPF. The nuclear localization of A1 is dependent on ongoing RNA polymerase II transcription.
Alternate names: Importin beta-2, KPNB2, Karyopherin beta-2, M9 region interaction protein, MIP1, TRN
Gene ID 3842
NCBI Accession NP_002261
UniProt Q92973
Research Area Transporters
Pathways PI3K-Akt Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
Application Notes Suitable for ELISA, Western blot (1/1000), Immunoprecipitation and Immunofluorescence. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Protocol Immunofluorescence protocol - Formaldehyde fixationCollect cells from T. c. unit and remove media from petri dish using suction. Wash with 1x PBS and remove. Incubate cells in pre-warm (37°C) Para-Formaldehyde for 12 minutes at room temperatureon an orbital shaker. Remove PFA and incubate in 0. 5% Triton X-IOO in 1x PBS for 5 minutes at room
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS with 0.09% Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Supplier Images
Western Blotting (WB) image for anti-Transportin 1 antibody (TNPO1) (ABIN112070) Figure 1. Western blot for anti-Transportin 1 antibody ABIN112070 on HeLa cell extracts.
Background publications Siomi, Eder, Kataoka et al.: "Transportin-mediated nuclear import of heterogeneous nuclear RNP proteins." in: The Journal of cell biology, Vol. 138, Issue 6, pp. 1181-92, 1997 (PubMed).

Catalog No. ABIN112070

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