Cyclin-Dependent Kinase 7 (CDK7) antibody

Details for Product No. ABIN112141
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Antigen
Reactivity
Human, Rat (Rattus)
(163), (59), (34), (16), (16), (15), (7), (1), (1)
Host
Mouse
(122), (50)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(5), (5), (5), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1)
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Flow Cytometry (FACS), Immunofluorescence (IF), Western Blotting (WB)
(133), (66), (52), (32), (29), (20), (20), (16), (15), (12), (8), (4), (3), (2), (1)
Pubmed 4 references available
Quantity 0.5 mL
Shipping to United States (Change)
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Catalog No. ABIN112141
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Immunogen Recombinant Human CDK7 / CAK protein.
Clone 01-01-14
Isotype IgG2b
Specificity This antibody is specific to Human CAK (CDK-activating kinase) a 40 kDa protein.
Cellular Localization: Cytoplasmic.
Purification Supernatant
Alternative Name CDK7
Background CDK7 is cdk activating kinase associated with the 34 kDa cyclin H protein, and a 36 kDa unnamed protein. CDK7/cyclin H is an integral part of the general transcription factor complex TFIIH, hence is important for activated transcription of polymerase II-dependent promoters and DNA repair. CDK7 is nuclear at all stages of the cell division cycle, except for mitosis indicating that its activity is required for key CDKs operating in distinct cell cycle phases.Synonyms: 39 kDa protein kinase, CAK1, CDK-activating kinase, Cell division protein kinase 7, P39 Mo15, STK1, TFIIH basal transcription factor complex kinase subunit
Gene ID 1022
NCBI Accession NP_001790
UniProt P50613
Research Area Cell Cycle
Application Notes Immunohistochemistry on frozen sections: dilute 1: 20-1: 40 in an ABC method (60 minutesat room temperature). Also useful for Western blotting, Immunocytochemistry and Flow Cytometry. Positive Control: Tonsil
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer 0.09 % Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
anti-Cyclin-Dependent Kinase 7 (CDK7) antibody Paraformaldehyde-fixed human cervical cancer cells (HeLa) stained cdk7 Ab using peroxidase-conjugate and AEC chromogen. Note nuclear staining of cultured cells
Background publications Feaver, Svejstrup, Henry et al.: "Relationship of CDK-activating kinase and RNA polymerase II CTD kinase TFIIH/TFIIK." in: Cell, Vol. 79, Issue 6, pp. 1103-9, 1995 (PubMed).

General Roy, Adamczewski, Seroz et al.: "The MO15 cell cycle kinase is associated with the TFIIH transcription-DNA repair factor." in: Cell, Vol. 79, Issue 6, pp. 1093-101, 1995 (PubMed).

Fisher, Morgan: "A novel cyclin associates with MO15/CDK7 to form the CDK-activating kinase." in: Cell, Vol. 78, Issue 4, pp. 713-24, 1994 (PubMed).

Mäkelä, Tassan, Nigg et al.: "A cyclin associated with the CDK-activating kinase MO15." in: Nature, Vol. 371, Issue 6494, pp. 254-7, 1994 (PubMed).

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