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Catenin (Cadherin-Associated Protein), delta 2 (Neural Plakophilin-Related Arm-Repeat Protein (CTNND2) (AA 292-309) antibody

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Antigen
  • Catnd2
  • CTNND2
  • ctnnd2
  • GT24
  • neurojugin
  • NPRAP
  • Nprap
  • si:dkey-40c17.4
Epitope
AA 292-309
13
9
5
3
2
1
1
1
1
Reactivity
Cow (Bovine), Human, Mouse (Murine), Rat (Rattus), Zebrafish (Danio rerio)
20
9
4
3
1
Host
Mouse
13
9
2
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
1
1
1
1
1
1
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
23
11
11
5
3
1
1
Supplier
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Immunogen Synthetic peptide J6 (corresponding to aa 292-309), coupled to KLH
Clone J19
Isotype IgG1
Specificity This Monoclonal antibody reacts specifically with Neurojungin (delta-catenin,a unique 160 kDa polypeptide of the plakoglobin / armadillo protein family) present in adhering type junctions in the nervous system, primarily expressed in the brain. Deltacatenin also binds to Presenilin-1, mutations of this protein are described to play a role in familial Alzheimer's disease. No cross-reaction with other members of the Armadillo / Plakoglobin protein family. The antibody is positive with a 300 kDa polypetide in Endothelia from blood vessels.
Cross-Reactivity (Details) Species reactivity (tested):Human, Bovine, Rat, Mouse, Zebrafish.
Purification Supernatant
Alternative Name Catenin delta-2 (CTNND2 Antibody Abstract)
Background Delta-Catenin, is a member of the p120 catenin subfamily of catenins. Delta-Catenin/NPRAP was identified as a protein homologous to plakophilin 1 and as a protein interacting with the loop region of presenilin 1 (PS1), the gene most commonly mutated in Alzheimer's disease. Delta-Catenin/NPRAP is almost exclusively expressed in the central nervous system mainly during early brain development. Delta-Catenin/NPRAP has been shown to co-localize and interact with N-cadherin in the mouse brain and to undergo dynamic relocalization during brain development.Synonyms: ARM-repeat protein, CTNND2, Delta-catenin, GT24, NPRAP, Neural plakophilin-related, Neurojungin
Gene ID 1501
NCBI Accession NP_001323
UniProt Q9UQB3
Research Area Signaling
Application Notes Immunoblotting. Immunohistochemistry on frozen and paraffin (only after microwave treatment) sections: Ready-to-use.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Handling Advice Dilute only prior to immediate use
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8 °C prior to opening. DO NOT FREEZE! Store reagent in the dark. Use subdued lighting during handling and incubation of cells prior to analysis.
Background publications Hatzfeld: "The p120 family of cell adhesion molecules." in: European journal of cell biology, Vol. 84, Issue 2-3, pp. 205-14, 2005 (PubMed).

Kosik, Donahue, Israely, Liu, Ochiishi: "Delta-catenin at the synaptic-adherens junction." in: Trends in cell biology, Vol. 15, Issue 3, pp. 172-8, 2005 (PubMed).

Paffenholz, Kuhn, Grund, Stehr, Franke: "The arm-repeat protein NPRAP (neurojungin) is a constituent of the plaques of the outer limiting zone in the retina, defining a novel type of adhering junction." in: Experimental cell research, Vol. 250, Issue 2, pp. 452-64, 1999 (PubMed).