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Desmoglein 1 (DSG1) antibody

Antigen

Desmoglein 1 (DSG1)
Synonyms DG1, DSG, CDHF4, PPKS1, SPPK1, DSG1, DSG-1
Clonality Monoclonal (Dsg1-P124)
Host
Alternatives

Mouse
Reactivity
Alternatives

Human
Conjugate
Alternatives Un-conjugated
Application
Alternatives Immunohistochemistry (Frozen Sections) (IHC (fro)), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
3 references available
Catalog no. ABIN112240
Quantity 5 mL
Price 385.00 $   Plus shipping costs $45.00
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Additional Information
Application Details Publications Alternatives back to top

Alternative name Desmoglein-1
UniProt Q02413
Immunogen Recombinant human polypeptide Desmoglein 1 (extracellular part EII, EIII and EIV)
Cross-Reactivity Human
Isotype IgG2a
Clone Dsg1-P124
Description Desmosomes are cell-cell junctions between epithelial, myocardial and certain other celltypes. Desmoglein 1 is a calcium-binding transmembrane glycoprotein component ofdesmosomes in vertebrate epithelial cells. Currently, three desmoglein subfamily membershave been identified and all are members of the cadherin cell adhesion moleculesuperfamily. These desmoglein gene family members are located in a cluster onchromosome 18. Desmoglein 1 has been identified as the autoantigen of the autoimmuneskin blistering disease pemphigus foliaceus. Desmoglein 1 is a 165kD glycoprotein that is a core component of the desmosome cell-celljunction between epithelial cells. Desmoglein 1 is synthesized in the suprabasal layer ofthe skin, and is vital to epidermal integrity.
Characteristics Synonyms: Desmosomal glycoprotein 1, Pemphigus foliaceus antigen, DSG1, CDHF4, DG1, DGI,Cadherin family member 4

Application Details
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Application Notes Immunohistochemistry on frozen sections: Ready-to-use, 1 h at RT, preincubation with 0.05- 0.2% Triton X-100 for 5 - 10 min, depending on tissue type, is recommended. Immunohistochemistry on paraffin-embedded tissue after MICROWAVE treatment: Ready-to-use, 1 h at RT, preincubation with 0.001% trypsin and addition of 2% milk powderto the incubation media is recommended. Immunoblotting. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Purification Supernatant
Storage Store the antibody undiluted at 2-8°C. DO NOT FREEZE! Shelf life: one year from despatch.
Research Area Cytoskeleton
Restrictions For Research Use only

Publications
Application Details Alternatives back to top

Kurzen, Moll, Moll et al.: "Compositionally different desmosomes in the various compartments of the human hair follicle." in: Differentiation; research in biological diversity, Vol. 63, Issue 5, pp. 295-304, 1998 (PubMed).

Akat, Mennel, Kremer et al.: "Molecular characterization of desmosomes in meningiomas and arachnoidal tissue." in: Acta neuropathologica, Vol. 106, Issue 4, pp. 337-47, 2003 (PubMed).

Waschke, Bruggeman, Baumgartner et al.: "Pemphigus foliaceus IgG causes dissociation of desmoglein 1-containing junctions without blocking desmoglein 1 transinteraction." in: The Journal of clinical investigation, Vol. 115, Issue 11, pp. 3157-65, 2005 (PubMed).