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Desmoglein 1 antibody (DSG1)

Details for Product anti-DSG1 Antibody No. ABIN112240, Supplier: Login to see New
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Synonyms DSG1, CDHF4, DG1, DSG, PPKS1, SPPK1, Dsg1b, Dsg1c, DSG-1, BB010119, Dsg1
(89), (10), (5), (2), (2), (2), (2), (2), (1), (1)
(40), (32), (18)
Clonality (Clone)
Monoclonal ()
This Desmoglein 1 antibody is un-conjugated
(4), (4), (3), (3), (3), (3), (1)
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(61), (40), (23), (21), (19), (19), (12), (3), (2), (2), (2)
Pubmed 4 references available
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Quantity 5 mL
Shipping to United States ( )
Availability Will be delivered in 6 to 8 Business Days
Immunogen Recombinant Human polypeptide Desmoglein 1 (extracellular part EII, EIII and EIV)
Clone Dsg1-P124
Isotype IgG2a
Specificity In Immunoblots of cytoskeletal preparations from Human skin the antibody reacts specifically with a 160 kDa polypeptide typical for Desmoglein 1. In immunolocalization studies the Mab shows typical staining of suprabasal layers of the epidermis and special regions of fetal anagen hair follicles. The staining pattern observed corresponds to those obtained with pemphigus foliaceus patient sera. Cross-reaction with Desmogleins 2 and 3 was not detected.
Purification Supernatant
Alternative Name Desmoglein-1 (DSG1 Antibody Abstract)
Background Desmosomes are cell-cell junctions between epithelial, myocardial and certain other cell types. Desmoglein 1 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. Desmoglein 1 has been identified as the autoantigen of the autoimmune skin blistering disease pemphigus foliaceus. Desmoglein 1 is a 165kD glycoprotein that is a core component of the desmosome cell-cell junction between epithelial cells. Desmoglein 1 is synthesized in the suprabasal layer of the skin, and is vital to epidermal integrity.Synonyms: CDHF4, Cadherin family member 4, DG1, DGI, DSG1, Desmosomal glycoprotein 1, Pemphigus foliaceus antigen
Gene ID 1828
NCBI Accession NP_001933
UniProt Q02413
Research Area Cytoskeleton
Application Notes Immunohistochemistry on frozen sections: Ready-to-use, 1 h at RT, preincubation with 0.05- 0.2 % Triton X-100 for 5 - 10 min, depending on tissue type, is recommended. Immunohistochemistry on paraffin-embedded tissue after MICROWAVE treatment: Ready-to-use, 1 h at RT, preincubation with 0.001 % trypsin and addition of 2 % milk powderto the incubation media is recommended. Immunoblotting.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer 0.09 % Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Background publications Waschke, Bruggeman, Baumgartner et al.: "Pemphigus foliaceus IgG causes dissociation of desmoglein 1-containing junctions without blocking desmoglein 1 transinteraction." in: The Journal of clinical investigation, Vol. 115, Issue 11, pp. 3157-65, 2005 (PubMed).

Akat, Mennel, Kremer et al.: "Molecular characterization of desmosomes in meningiomas and arachnoidal tissue." in: Acta neuropathologica, Vol. 106, Issue 4, pp. 337-47, 2003 (PubMed).

Kurzen, Moll, Moll et al.: "Compositionally different desmosomes in the various compartments of the human hair follicle." in: Differentiation; research in biological diversity, Vol. 63, Issue 5, pp. 295-304, 1998 (PubMed).

Schäfer, Stumpp, Franke: "Immunological identification and characterization of the desmosomal cadherin Dsg2 in coupled and uncoupled epithelial cells and in human tissues." in: Differentiation; research in biological diversity, Vol. 60, Issue 2, pp. 99-108, 1996 (PubMed).

Catalog No. ABIN112240
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