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Ubiquitin antibody

Details for Product No. ABIN112508, Supplier: Login to see
Antigen
  • CG11624
  • DmUb
  • DmUbi-p63E
  • Dmel\\CG11624
  • Ub
  • Ubi-P63e
  • Ubi-p
  • Ubi63E
  • Ubi63p
  • Ubip
  • Ubiq
  • Ubp
  • ubi
  • ubi-p63E
  • ubi63E
  • CG18282
  • CG32744
  • CR32744
  • DmUbi-p5E
  • Dmel\\CG32744
  • ubiquitin
  • si:dz180g5.5
  • si:busm1-180g5.5
  • LOC100194618
  • UBIQ
  • Ubiquitin
  • LOC100282068
Reactivity
Human
269
199
124
119
39
29
29
26
24
24
24
22
22
22
21
20
10
8
4
2
2
2
2
2
1
1
1
1
1
Host
Mouse
216
168
6
5
3
1
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
17
14
12
12
12
11
5
5
5
5
5
5
5
5
5
5
5
2
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
304
196
138
85
81
73
46
31
24
12
11
9
4
3
2
1
Supplier
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Immunogen Purified ubiquitin covalently coupled to KLH using glutaraldehyde.
Clone 242-9
Isotype IgG1
Specificity Ubiquitin (76 amino acid, 8.5 kDa). Shows staining of tangle material in Alzheimer affected brain, and also stains other pathological inclusions such as Lewy bodies (in Parkinsons disease) and Pick bodies (in Picks disease).
Purification Ascites
Background Synonyms: Polyubiquitin-B, UBB
Gene ID 7314
UniProt P0CG47
Research Area Neurology, Proteolysis / Ubiquitin, Alzheimer's Disease, Proteases, Amino Acids
Pathways
Application Notes Immunohistochemistry on frozen and paraffin sections: 1/250-1/1000. Western Blot: Sensitivity can be enhanced by autoclaving the blot.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment The antibody can be shipped at 2-8 °C. Store (in aliquots) at -20 °C only.
Background publications Perry, Friedman, Shaw et al.: "Ubiquitin is detected in neurofibrillary tangles and senile plaque neurites of Alzheimer disease brains." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 84, Issue 9, pp. 3033-6, 1987 (PubMed).

Meyer, West, Chau: "Antibodies directed against ubiquitin inhibit high affinity [3H]choline uptake in rat cerebral cortical synaptosomes." in: The Journal of biological chemistry, Vol. 261, Issue 31, pp. 14365-8, 1986 (PubMed).

Shaw, Chau: "Ubiquitin and microtubule-associated protein tau immunoreactivity each define distinct structures with differing distributions and solubility properties in Alzheimer brain." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 85, Issue 8, pp. 2854-8, 1988 (PubMed).

Askanas, Engel, Alvarez: "Strong immunoreactivity of beta-amyloid precursor protein, including the beta-amyloid protein sequence, at human neuromuscular junctions." in: Neuroscience letters, Vol. 143, Issue 1-2, pp. 96-100, 1992 (PubMed).

Askanas, Serdaroglu, Engel et al.: "Immunocytochemical localization of ubiquitin in inclusion body myositis allows its light-microscopic distinction from polymyositis." in: Neurology, Vol. 42, Issue 2, pp. 460-1, 1992 (PubMed).