Ubiquitin antibody

Details for Product No. ABIN112508
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Antigen
Synonyms
CG11624, DmUb, DmUbi-p63E, Dmel\\CG11624, Ub, Ubi-P63e, Ubi-p, Ubi63E, Ubi63p, Ubip, Ubiq, Ubp, ubi, ubi-p63E, ubi63E, CG18282, CG32744, CR32744, DmUbi-p5E, Dmel\\CG32744, ubiquitin, si:dz180g5.5, si: ... show more
CG11624, DmUb, DmUbi-p63E, Dmel\\CG11624, Ub, Ubi-P63e, Ubi-p, Ubi63E, Ubi63p, Ubip, Ubiq, Ubp, ubi, ubi-p63E, ubi63E, CG18282, CG32744, CR32744, DmUbi-p5E, Dmel\\CG32744, ubiquitin, si:dz180g5.5, si:busm1-180g5.5, LOC100194618, UBIQ, Ubiquitin, LOC100282068 show less
Reactivity
Human
(162), (109), (61), (60), (15), (13), (9), (9), (8), (6), (6), (6), (4), (4), (4), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1)
Host
Mouse
(144), (113), (4), (2), (2), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(10), (6), (5), (5), (5), (4), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Frozen Paraffin-embedded Sections) (IHC (frpe)), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(186), (115), (82), (66), (34), (30), (24), (21), (18), (14), (12), (10), (2), (1)
Pubmed 5 references available
Quantity 0.1 mL
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
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Catalog No. ABIN112508
797.50 $
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Immunogen Purified ubiquitin covalently coupled to KLH using glutaraldehyde.
Clone 242-9
Isotype IgG1
Specificity Ubiquitin (76 amino acid, 8.5 kDa). Shows staining of tangle material in Alzheimer affected brain, and also stains other pathological inclusions such as Lewy bodies (in Parkinsons disease) and Pick bodies (in Picks disease).
Purification Ascites
Background Synonyms: Polyubiquitin-B, UBB
Gene ID 7314
UniProt P0CG47
Research Area Neurology, Proteolysis / Ubiquitin, Alzheimer's Disease, Proteases, Amino Acids
Application Notes Immunohistochemistry on frozen and paraffin sections: 1/250-1/1000. Western Blot: Sensitivity can be enhanced by autoclaving the blot.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment The antibody can be shipped at 2-8 °C. Store (in aliquots) at -20 °C only.
Background publications Askanas, Serdaroglu, Engel et al.: "Immunocytochemical localization of ubiquitin in inclusion body myositis allows its light-microscopic distinction from polymyositis." in: Neurology, Vol. 42, Issue 2, pp. 460-1, 1992 (PubMed).

Shaw, Chau: "Ubiquitin and microtubule-associated protein tau immunoreactivity each define distinct structures with differing distributions and solubility properties in Alzheimer brain." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 85, Issue 8, pp. 2854-8, 1988 (PubMed).

Meyer, West, Chau: "Antibodies directed against ubiquitin inhibit high affinity [3H]choline uptake in rat cerebral cortical synaptosomes." in: The Journal of biological chemistry, Vol. 261, Issue 31, pp. 14365-8, 1986 (PubMed).

Perry, Friedman, Shaw et al.: "Ubiquitin is detected in neurofibrillary tangles and senile plaque neurites of Alzheimer disease brains." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 84, Issue 9, pp. 3033-6, 1987 (PubMed).

General Askanas, Engel, Alvarez: "Strong immunoreactivity of beta-amyloid precursor protein, including the beta-amyloid protein sequence, at human neuromuscular junctions." in: Neuroscience letters, Vol. 143, Issue 1-2, pp. 96-100, 1992 (PubMed).

Validation Images
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