Tetanus Toxin antibody (AA 1300-1314)

Catalog No. ABIN112840

Product Details anti-Tetanus Toxin Antibody

Target: Tetanus Toxin (TetX)

Binding Specificity: AA 1300-1314

Reactivity: Clostridium tetani

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Tetanus Toxin antibody is un-conjugated

Application: Enzyme Immunoassay (EIA)

Specificity: This antibody detects Tetanus Toxin.

Purification: Affinity Chromatography on Protein A.

Immunogen: Synthetic peptide corresponding to the amino acids 1300-1314 of the native molecule conjugated to Keyhole limpet Haemocyanin.

Application Details

Application Notes: ELISA.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.1 mg/mL

Buffer: PBS, pH 7.2 containing 0.09 % Sodium Azide as preservative.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for Tetanus Toxin

Target: Tetanus Toxin (TetX)

Alternative Name: Tetanus Toxin (TetX Products)

Target Type: Bacteria

Background: Tetanus toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that catalyzes the hydrolysis of the 76-Gln-|-Phe-77 bond of synaptobrevin-2. The precursor polypeptide is subsequently cleaved to yield subchains L and H. These remain linked by a disulfide bridge and are non-toxic after separation.Synonyms: Clostridium tetani toxin, tetX

Gene ID: 1061100

NCBI Accession: NP_783831

UniProt: P04958