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APOE antibody (Apolipoprotein E)

Details for Product anti-APOE Antibody No. ABIN112982, Supplier: Log in to see
Antigen
  • ad2
  • apoprotein
  • im:7036787
  • wu:fb69a05
  • zgc:110064
  • apoe
  • AI255918
  • AD2
  • LDLCQ5
  • LPG
  • APOEA
  • Apo-E
Reactivity
Mouse (Murine)
269
62
34
7
5
2
1
Host
Rabbit
139
106
74
Clonality
Polyclonal
Conjugate
This APOE antibody is un-conjugated
24
18
12
5
5
5
3
1
1
1
1
1
1
1
1
1
1
1
Application
Immunodiffusion (ID), Western Blotting (WB)
221
187
70
52
15
15
14
13
9
6
6
5
5
3
3
2
2
2
2
2
2
2
1
1
1
1
Supplier
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Immunogen Purified Mouse Apolipoprotein E from pooled mouse plasma high and very low density lipoproteins
Specificity This antibody detects Apo E.
Cross-Reactivity (Details) Species reactivity (tested):Mouse, human (extremely low)
Purification Serum
Alternative Name Apolipoprotein E (Apo E) (APOE Antibody Abstract)
Background Apolipoprotein E is essential for the normal catabolism of triglyceride rich lipoprotein constituents. The apolipoprotein E gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in Apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. Mutations in the APOE gene confer susceptibility to Alzheimer's disease by affecting amyloid-beta deposition.Synonyms: Apo-E, ApoE
Gene ID 11816
NCBI Accession NP_033826
UniProt P08226
Research Area Metabolism
Pathways
Application Notes Radial immunodiffusion assay (1: 40)Immuno double-diffusion. Rocket IEP. Western blot (1: 500 - 1: 1,000).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Handling Advice Avoid repeated freezing and thawing. Dilute only prior to immediate use.
Storage -20 °C
Storage Comment Store the antibody undiluted (in aliquots) at -20 °C.
Background publications Hayhurst, Lee, Lambert et al.: "Hepatocyte nuclear factor 4alpha (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis." in: Molecular and cellular biology, Vol. 21, Issue 4, pp. 1393-403, 2001 (PubMed).