anti-beta Amyloid antibody (Amyloid beta) (AA 3-16)

Details for Product anti-Abeta Antibody No. ABIN113075
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AA 3-16
(89), (52), (25), (24), (11), (9), (5), (5), (5), (4), (4), (4), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Mouse (Murine), Rat (Rattus)
(230), (22), (11), (7), (2), (2), (2), (1), (1), (1), (1)
(183), (58), (2), (1)
This beta Amyloid antibody is un-conjugated
(18), (8), (5), (5), (5), (5)
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(165), (140), (56), (54), (36), (35), (35), (22), (14), (8), (5), (5), (4), (3), (2), (2), (2), (1), (1)
Pubmed 2 references available
Quantity 0.2 mL
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Immunogen Rat/Mouse Amyloid Beta peptide, amino acids 3-16.
Purification Purified
Alternative Name Amyloid beta (Abeta Antibody Abstract)
Background Amyloid beta precursor protein gene (ABPP) encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Multiple transcript variants encoding several different isoforms have been found for this gene. Isoform APP695 is the predominant form in neuronal tissue, isoform APP751 and isoform APP770 are widely expressed in nonneuronal cells. Isoform APP751 is the most abundant form in T lymphocytes. ABPP is expressed in all fetal tissues examined with the highest levels in brain, kidney, heart and spleen with weak expression observed in liver, ABPP is induced during neuronal differentiation. In the adult brain, highest expression of ABPP gene is found in the frontal lobe of the cortex and in the anterior perisylvian cortex opercular gyri, moderate expression in the cerebellar cortex, the posterior perisylvian cortex opercular gyri and the temporal associated cortex. Weak expression is found in the striate, extra striate and motor cortices. Mutations in ABPP have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy).Synonyms: Amyloid beta peptide
Research Area Neurology, Alzheimer's Disease
Application Notes Suitable for use in IHC (Formalin-Fixed, Paraffin-Embedded sections: working dilution1/250-1/500). Not recommended for use in ELISA and Western blot.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS buffer without preservatives.
Preservative Without preservative
Precaution of Use Do Not Add Sodium Azide
Handling Advice Avoid repeated freezing and thawing. Dilute only prior to immediate use
Storage 4 °C/-20 °C
Storage Comment Store vial at 2-8 °C prior to restoration. For extended storage add glycerol to 50% and then aliquot contents and freeze at -20 °C or below. Centrifuge product if not completely clear after standing at room temperature. This antibody is stable for one month at 2-8 °C as an undiluted liquid.
Background publications Potempska, Mack, Mehta et al.: "Quantification of sub-femtomole amounts of Alzheimer amyloid beta peptides." in: Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis, Vol. 6, Issue 1, pp. 14-21, 1999 (PubMed).

General Emmerling, Morganti-Kossmann, Kossmann et al.: "Traumatic brain injury elevates the Alzheimer's amyloid peptide A beta 42 in human CSF. A possible role for nerve cell injury." in: Annals of the New York Academy of Sciences, Vol. 903, pp. 118-22, 2000 (PubMed).

Catalog No. ABIN113075
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