Amyloid beta (Abeta) (AA 32-40) antibody

Details for Product No. ABIN113076
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Antigen
Synonyms aaa, abeta, abpp, ad1, appi, ctfgamma, cvap, pn2, APP, ABPP
Epitope
AA 32-40
(54), (37), (20), (12), (8), (6), (5), (4), (4), (3), (3), (3), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(158), (23), (11), (3), (2), (2), (1), (1), (1), (1)
Host
Rabbit
(123), (56), (2), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(11), (3)
Application
ELISA, Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(121), (117), (52), (40), (36), (35), (18), (14), (5), (4), (2), (1), (1)
Pubmed 7 references available
Quantity 0.1 mL
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Catalog No. ABIN113076
522.50 $
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Immunogen Peptide (amino acids 32-40) conjugated to keyhole limpet hemocyanin (KLH).
Specificity Specific for the C-terminus of Amyloid beta 1-40. Reacts extremely well with the 1-40 isoform. Does not cross-react with Amyloid beta 1-42 or Amyloid Precursor Protein (APP).
Purification Purified
Alternative Name Amyloid beta
Background Amyloid beta precursor protein gene (ABPP) encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Multiple transcript variants encoding several different isoforms have been found for this gene. Isoform APP695 is the predominant form in neuronal tissue, isoform APP751 and isoform APP770 are widely expressed in nonneuronal cells. Isoform APP751 is the most abundant form in T lymphocytes. ABPP is expressed in all fetal tissues examined with the highest levels in brain, kidney, heart and spleen with weak expression observed in liver, ABPP is induced during neuronal differentiation. In the adult brain, highest expression of ABPP gene is found in the frontal lobe of the cortex and in the anterior perisylvian cortex opercular gyri, moderate expression in the cerebellar cortex, the posterior perisylvian cortex opercular gyri and the temporal associated cortex. Weak expression is found in the striate, extra striate and motor cortices. Mutations in ABPP have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy).
Alternate names: Amyloid beta peptide
Research Area Neurology, Alzheimer's Disease
Application Notes ELISAWestern blotImmunohistochemistry: Epitope must be re-exposed in fixed tissue by pretreatment oftissue using one of the following procedures: 1. Formic acid (70 %) for 10-30 minutes at room temperature.2. HIER (heat Induced Epitope Retrieval) with buffers. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS containing no preservatives.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Potempska, Mack, Mehta et al.: "Quantification of sub-femtomole amounts of Alzheimer amyloid beta peptides." in: Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis, Vol. 6, Issue 1, pp. 14-21, 1999 (PubMed).

Mayeux, Tang, Jacobs et al.: "Plasma amyloid beta-peptide 1-42 and incipient Alzheimer's disease." in: Annals of neurology, Vol. 46, Issue 3, pp. 412-6, 1999 (PubMed).

Mehta, Pirttilä, Mehta et al.: "Plasma and cerebrospinal fluid levels of amyloid beta proteins 1-40 and 1-42 in Alzheimer disease." in: Archives of neurology, Vol. 57, Issue 1, pp. 100-5, 2000 (PubMed).

Emmerling, Morganti-Kossmann, Kossmann et al.: "Traumatic brain injury elevates the Alzheimer's amyloid peptide A beta 42 in human CSF. A possible role for nerve cell injury." in: Annals of the New York Academy of Sciences, Vol. 903, pp. 118-22, 2000 (PubMed).

Tapiola, Pirttilä, Mehta et al.: "Relationship between apoE genotype and CSF beta-amyloid (1-42) and tau in patients with probable and definite Alzheimer's disease." in: Neurobiology of aging, Vol. 21, Issue 5, pp. 735-40, 2000 (PubMed).

Schupf, Patel, Silverman et al.: "Elevated plasma amyloid beta-peptide 1-42 and onset of dementia in adults with Down syndrome." in: Neuroscience letters, Vol. 301, Issue 3, pp. 199-203, 2001 (PubMed).

Mehta, Pirttila, Patrick et al.: "Amyloid beta protein 1-40 and 1-42 levels in matched cerebrospinal fluid and plasma from patients with Alzheimer disease." in: Neuroscience letters, Vol. 304, Issue 1-2, pp. 102-6, 2001 (PubMed).

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