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LDLR antibody (Low Density Lipoprotein Receptor)

Details for Product anti-LDLR Antibody No. ABIN113459, Supplier: Log in to see
Antigen
  • FH
  • FHC
  • LDLCQ2
  • Hlb301
  • LDLRA
  • LDLA
Reactivity
Human
103
46
17
13
12
5
1
1
1
1
1
1
Host
Chicken
89
33
4
2
Clonality
Polyclonal
Conjugate
This LDLR antibody is un-conjugated
11
5
4
3
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Flow Cytometry (FACS), Immunofluorescence (IF), Western Blotting (WB)
86
45
41
16
12
11
11
8
7
5
2
2
1
1
1
Supplier
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Immunogen Recombinant human LDL receptor domain I, II, III region.
Specificity The antibody is directed against the extracellular domains I, II, III within the ligand binding region of the human LDL receptor.
Purification Purified
Alternative Name LDLR (LDLR Antibody Abstract)
Background The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. The LDL receptor (160 kD mature or glycosylated receptor, 120 kD precursor or unglycosylated receptor) plays a key role in cellular cholesterol homeostasis.Synonyms: LDL receptor, LDLR, Low-density lipoprotein receptor
Gene ID 3949
NCBI Accession NP_000518
UniProt P01130
Pathways
Application Notes ELISA. Western blot: 1/50. Flow Cytometry: 1/10. Receptor-binding studies. Immunofluorescence: 1/50 - 1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer PBS, pH 7.4 containing 0.5 % BSA and Penicillin/Streptomycin for stabilization.
Storage -20 °C
Storage Comment Store the lyophilized antibody at -20 °C.
Background publications Eden, Patel, Sun et al.: "Restoration of LDL receptor function in cells from patients with autosomal recessive hypercholesterolemia by retroviral expression of ARH1." in: The Journal of clinical investigation, Vol. 110, Issue 11, pp. 1695-702, 2002 (PubMed).