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Perilipin 1 (PLIN1) (AA 1-20), (N-Term) antibody

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Synonyms PLIN, peri, plin, perilipin, LOC692833, FPLD4, PERI, 6030432J05Rik, Peri, Plin, PERIA
AA 1-20, N-Term
(41), (13), (11), (7), (7), (3), (3), (2), (1), (1), (1), (1), (1), (1), (1)
Cow (Bovine), Human, Mouse (Murine), Rat (Rattus)
(85), (43), (40), (9), (8), (8), (2), (2), (1), (1), (1)
Guinea Pig
(47), (40), (6), (6), (3)
(4), (4), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(88), (40), (19), (14), (11), (10), (5), (2), (2)
Pubmed 6 references available
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Quantity 0.1 mL
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Availability Will be delivered in 6 to 8 Business Days
Immunogen Duplicated N-terminus of Perilipin, aa 1-20 (cf. Greenberg et al. 1992, JBC 266, 11341-11346)
Specificity The antiserum reacts specifically with Perilipins (A and B) located at the surface of intracellular storage lipid droplets present e.g. in the adrenal gland, adipocytes of white and brown adipose tissue and cultured cells such as 3T3-L1 adipocytes and cultured steroidogenic adrenal cortical and Leydig cells. It also is a useful pathological marker since PLIN1 becames expressed de novo in hepatocyte steatogenesis. This antiserum does not cross-react with ADRP (Adipophilin) or TIP47 proteins (additional members of the PAT-family).
Cross-Reactivity (Details) Species reactivity (tested):Human, Bovine, Rat and Mouse.
Purification Serum
Alternative Name Perilipin-1 (PLIN1 Antibody Abstract)
Background Perilipins build a family of phosphoproteins. The predominant forms in adipocytes, Perilipin A and B, arise by alternative RNA splicing from a single gene, generating polypeptides of 57 and 46 kD, respectively. The N-terminus, however, remains unchanged.Synonyms: Lipid Droplet-Associated Protein, PERI, PLIN, PLIN-1, PLIN1, Perilipin
Gene ID 5346
NCBI Accession NP_002657
UniProt O60240
Research Area Metabolism
Application Notes Immunoblotting (Western blotting): 1/2000 (ECL). Immunohistochemistry on Frozen Tissue. Immunohistochemistry on Paraffin Sections: 1/100-200 when using microwave treatment. Incubation Time: 1h at RT for Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8 °C.
Product cited in: Forcioli-Conti, Lacas-Gervais, Dani et al.: "The primary cilium undergoes dynamic size modifications during adipocyte differentiation of human adipose stem cells." in: Biochemical and biophysical research communications, Vol. 458, Issue 1, pp. 117-22, 2015 (PubMed).

Kolak, Westerbacka, Velagapudi et al.: "Adipose tissue inflammation and increased ceramide content characterize subjects with high liver fat content independent of obesity." in: Diabetes, Vol. 56, Issue 8, pp. 1960-8, 2007 (PubMed).

Background publications Martinez-Botas, Anderson, Tessier et al.: "Absence of perilipin results in leanness and reverses obesity in Lepr(db/db) mice." in: Nature genetics, Vol. 26, Issue 4, pp. 474-9, 2000 (PubMed).

Wolins, Rubin, Brasaemle: "TIP47 associates with lipid droplets." in: The Journal of biological chemistry, Vol. 276, Issue 7, pp. 5101-8, 2001 (PubMed).

Heid, Moll, Schwetlick et al.: "Adipophilin is a specific marker of lipid accumulation in diverse cell types and diseases." in: Cell and tissue research, Vol. 294, Issue 2, pp. 309-21, 1998 (PubMed).

Schiffmann, Dwyer, Lubensky et al.: "Constitutive achlorhydria in mucolipidosis type IV." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, Issue 3, pp. 1207-12, 1998 (PubMed).

Catalog No. ABIN113463
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