Catenin (Cadherin-Associated Protein), delta 2 (Neural Plakophilin-Related Arm-Repeat Protein (CTNND2) (AA 1175-1192) antibody

Details for Product No. ABIN113475
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Antigen
Synonyms GT24, NPRAP, Nprap, Catnd2, neurojugin, CTNND2
Epitope
AA 1175-1192
(4), (3), (2), (1), (1)
Reactivity
Cow (Bovine), Human, Mouse (Murine), Rat (Rattus)
(12), (5), (4), (3), (1)
Host
Guinea Pig
(8), (6), (1)
Clonality
Polyclonal
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(15), (5), (4), (2), (1), (1), (1)
Pubmed 3 references available
Catalog no. ABIN113475
Quantity 0.1 mL
Price
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Immunogen Synthetic peptide J7 (corresponding to aa 1175-1192), coupled to KLH
Specificity The antibody reacts specifically with Neurojungin (Delta-Catenin, a unique 160 kD polypeptide of the plakoglobin / armadillo protein family) present in adhering type junctions in the nervous system, primarily expressed in the brain. Delta-Catenin also binds to presenilin-1, mutations of this protein are described to play a role in familial Alzheimers disease. No cross-reaction with other members of the armadillo / Plakoglobin protein family. Tested Reactivities on Cultured Cell Lines: Murine cell line A1B2, stably transfected with Neurojungin cDNA Species Reactivity: Tested: Human, Bovine, Rat, Mouse.
Purification Serum
Alternative Name Catenin delta-2
Background Delta-Catenin, is a member of the p120 catenin subfamily of catenins. Delta- Catenin/NPRAP was identified as a protein homologous to plakophilin 1 and as a protein interacting with the loop region of presenilin 1 (PS1), the gene most commonly mutated in Alzheimers disease. Delta-Catenin/NPRAP is almost exclusively expressed in the central nervous system mainly during early brain development. Delta-Catenin/NPRAP has been shown to co-localize and interact with N-cadherin in the mouse brain and to undergo dynamic relocalization during brain development.
Alternate names: ARM-repeat protein, CTNND2, Delta-catenin, GT24, NPRAP, Neural plakophilin-related, Neurojungin
Gene ID 1501
NCBI Accession NP_001323.1
UniProt Q9UQB3
Research Area Signaling
Application Notes Immunoblotting: 1: 2500, using ECL. Immunofluorescence microscopy: 1: 100. Immunohistochemistry on frozen sections. Immunohistochemistry on paraffin sections: only after microwave treatment. Positive control: Murine brain, retinaOther applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer 0.09% Sodium Azide
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for up to six months or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Paffenholz, Kuhn, Grund et al.: "The arm-repeat protein NPRAP (neurojungin) is a constituent of the plaques of the outer limiting zone in the retina, defining a novel type of adhering junction." in: Experimental cell research, Vol. 250, Issue 2, pp. 452-64, 1999 (PubMed).

Kosik, Donahue, Israely et al.: "Delta-catenin at the synaptic-adherens junction." in: Trends in cell biology, Vol. 15, Issue 3, pp. 172-8, 2005 (PubMed).

Hatzfeld: "The p120 family of cell adhesion molecules." in: European journal of cell biology, Vol. 84, Issue 2-3, pp. 205-14, 2005 (PubMed).

Hosts (8), (6), (1)
Reactivities (12), (5), (4), (3), (1)
Applications (15), (5), (4), (2), (1), (1), (1)
Epitopes (4), (3), (2), (1), (1)
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