Desmocollin 2 (DSC2) antibody
| Antigen |
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| Synonyms |
DG2, DSC3, CDHF2, ARVD11, DGII/III, DKFZp686I11137, Dsc2a, Dsc2b, AW228162, DSC2, MGC124744 |
| Clonality |
Polyclonal |
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Host
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Reactivity
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Application
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 Alternatives Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
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| Catalog no. |
ABIN113477 |
| Quantity |
0.1 ml |
| Price |
380.00 $ Plus shipping costs $35.00
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| Shipping to |
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| Availability |
Ships within 7 to 10 Business Days |
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Characteristics
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Synonyms: Desmocollin-3, DSC2, CDHF2, DSC3, Desmosomal glycoprotein II and III, Cadherin familymember 2
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Alternative name
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Desmocollin-2
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Swiss-Prot
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Q02487
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Immunogen
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Extracellular part of human Desmocollin 2 (recombinant).
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Format
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Serum
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Description
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Desmocollin 2 is a calcium dependent glycoprotein that is a member of the desmocollinsubfamily of the cadherin superfamily. These desmosomal family members, along with thedesmogleins, are found primarily in epithelial cells where they constitute the adhesiveproteins of the desmosome cell-cell junction and are required for cell adhesion anddesmosome formation. Mutations in Desmocollin 2 are associated with arrhythmogenicright ventricular dysplasia 11. Alternative splicing results in two transcript variantsencoding distinct isoforms.
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Specificity
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Reacts with Desmocollin 2a and 2b (splice forms, mw 78 535, corresponding to 712 aminoacids). Localization: All desmosome-possessing cell types, including epithelia, myocardiac cellsand lymph nodes and neoplasia derived therefrom. Species: Human and Bovine. Others not tested.
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Application Notes
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Immunoblotting (Western). Cytological material. Immunohistochemistry on Frozen Sections and Paraffin Embedded Tissue. Incubation time: 1 h at RT, extended with paraffin. Working Dilutions: 1/100 for Frozen Sections.1/50 for Paraffin-Embedded tissue.1/2000 for Western Blotting. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
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Storage
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Store the antibody (undiluted) at 2-8°C. Shelf life: one year from despatch.
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Research Area
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Cytoskeleton
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Restrictions
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For Research Use only
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Publications
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Nuber, Schaefer, Schmidt et al.: "The widespread human desmocollin Dsc2 and tissue-specific patterns of synthesis of various desmocollin subtypes." in: European journal of cell biology, Vol. 66, Issue 1, pp. 69-74, 1995 (PubMed).
Moll, Houdek, Schaefer et al.: "Diversity of desmosomal proteins in regenerating epidermis: immunohistochemical study using a human skin organ culture model." in: Archives of dermatological research, Vol. 291, Issue 7-8, pp. 437-46, 1999 (PubMed).
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Alternatives for antigen "Desmocollin 2 (DSC2)", type "Antibodies"
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Hosts
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Rabbit (21), Guinea Pig (2)
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Reactivities
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Human (21), Mouse (Murine) (20), Rat (Rattus) (20), Dog (Canine) (15), Cow (Bovine) (1)
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Applications
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Flow Cytometry (FACS) (18), Immunofluorescence (IF) (18), Western Blotting (WB) (6), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (4), ELISA (3), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (2), Immunohistochemistry (Frozen Sections) (IHC (fro)) (2), Immunoprecipitation (IP) (2), Immunoelectron Microscopy (IEM) (1), Immunohistochemistry (IHC) (1)
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Conjugates
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Alexa Flour 488 (1), Alexa Fluor 350 (1), Alexa Fluor 488 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy5.5 (1), PE,Cy7 (1), RBITC (1)
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