»
Antibody
»
anti-Desmocollin 2 DSC2
Desmocollin 2 (DSC2) antibody
| Antigen |
|
| Synonyms |
DG2, DSC3, CDHF2, ARVD11, DGII/III, DKFZp686I11137, Dsc2a, Dsc2b, AW228162, DSC2, MGC124744 |
| Clonality |
Polyclonal |
|
Host
|
|
|
Reactivity
|
|
|
Application
|
 Alternatives Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
Flow Cytometry (FACS) (13), Immunofluorescence (IF) (13), Western Blotting (WB) (10), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (4), ELISA (3), ELISA (Detection) (3), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (2), Immunohistochemistry (Frozen Sections) (IHC (fro)) (2), Immunoprecipitation (IP) (2), Enzyme Immunoassay (EIA) (1), Immunoelectron Microscopy (EM) (1), Immunohistochemistry (IHC) (1)
|
| Catalog no. |
ABIN113477 |
| Quantity |
0.1 ml |
| Price |
380.00 $ Plus shipping costs $35.00
|
| Shipping to |
|
| Availability |
Ships within 7 to 10 Business Days |
|
Characteristics
|
Synonyms: Desmocollin-3, DSC2, CDHF2, DSC3, Desmosomal glycoprotein II and III, Cadherin familymember 2
|
|
Alternative name
|
Desmocollin-2
|
|
Swiss-Prot
|
Q02487
|
|
Immunogen
|
Extracellular part of human Desmocollin 2 (recombinant).
|
|
Format
|
Serum
|
|
Description
|
Desmocollin 2 is a calcium dependent glycoprotein that is a member of the desmocollinsubfamily of the cadherin superfamily. These desmosomal family members, along with thedesmogleins, are found primarily in epithelial cells where they constitute the adhesiveproteins of the desmosome cell-cell junction and are required for cell adhesion anddesmosome formation. Mutations in Desmocollin 2 are associated with arrhythmogenicright ventricular dysplasia 11. Alternative splicing results in two transcript variantsencoding distinct isoforms.
|
|
Specificity
|
Reacts with Desmocollin 2a and 2b (splice forms, mw 78 535, corresponding to 712 aminoacids). Localization: All desmosome-possessing cell types, including epithelia, myocardiac cellsand lymph nodes and neoplasia derived therefrom. Species: Human and Bovine. Others not tested.
|
|
Application Notes
|
Immunoblotting (Western). Cytological material. Immunohistochemistry on Frozen Sections and Paraffin Embedded Tissue. Incubation time: 1 h at RT, extended with paraffin. Working Dilutions: 1/100 for Frozen Sections.1/50 for Paraffin-Embedded tissue.1/2000 for Western Blotting. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
|
|
Storage
|
Store the antibody (undiluted) at 2-8°C. Shelf life: one year from despatch.
|
|
Research Area
|
Cytoskeleton
|
|
Restrictions
|
For Research Use only
|
|
Publications
|
Nuber, Schaefer, Schmidt et al.: "The widespread human desmocollin Dsc2 and tissue-specific patterns of synthesis of various desmocollin subtypes." in: European journal of cell biology, Vol. 66, Issue 1, pp. 69-74, 1995 (PubMed).
Moll, Houdek, Schaefer et al.: "Diversity of desmosomal proteins in regenerating epidermis: immunohistochemical study using a human skin organ culture model." in: Archives of dermatological research, Vol. 291, Issue 7-8, pp. 437-46, 1999 (PubMed).
|
Alternatives for antigen "Desmocollin 2 (DSC2)", type "Antibodies"
|
Hosts
|
Rabbit (17), Mouse (3), Guinea Pig (2)
|
|
Reactivities
|
Human (20), Dog (Canine) (15), Mouse (Murine) (15), Rat (Rattus) (15), Cow (Bovine) (1)
|
|
Applications
|
Flow Cytometry (FACS) (13), Immunofluorescence (IF) (13), Western Blotting (WB) (10), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (4), ELISA (3), ELISA (Detection) (3), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (2), Immunohistochemistry (Frozen Sections) (IHC (fro)) (2), Immunoprecipitation (IP) (2), Enzyme Immunoassay (EIA) (1), Immunoelectron Microscopy (EM) (1), Immunohistochemistry (IHC) (1)
|
|
Conjugates
|
Alexa Flour 488 (1), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy7 (1), RBITC (1)
|
