Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 4 (SLC2A4) (C-Term) antibody

Details for Product No. ABIN113521
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Antigen
Synonyms GLUT4, SLC2A4, Glut-4, Glut4, glut4, slc2a4
Epitope
C-Term
(17), (9), (5), (4), (4), (3), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Monkey, Mouse (Murine), Pig (Porcine), Rat (Rattus)
(77), (46), (43), (17), (14), (13), (3), (2), (1), (1), (1), (1)
Host
Rabbit
(57), (28), (4), (4)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunoprecipitation (IP), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(74), (35), (21), (21), (17), (10), (10), (8), (7), (5), (2), (2), (1)
Pubmed 3 references available
Quantity 0.1 mL
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Catalog No. ABIN113521
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Immunogen A 12 amino acid peptide corresponding to the carboxyl terminus of the insulin regulatable glucose transporter conjugated to Keyhole Limpet Hemocyanin.
Specificity This antibody recognizes Glucose Transporter 4 (GLUT4). It does not react with HEP G2 type Glucose Transporter in Human erythrocytes, Rat brain or other tissues that do not exhibit sensitivity to Insulin.
Purification Affinity Chromatography.
Alternative Name GLUT4 / SLC2A4
Background GLUT4 is the insulin-regulated glucose transporter found in adipose tissue and striated muscle, responsible for glucose disposal. The stimulation of glucose uptake by insulin requires translocation of the GLUT4 glucose transporter from intracellular storage sites to the cell surface. Activation of phosphatidylinositol-3-OH kinase (PI3K) is required for this trafficking event, but it is not sufficient to produce GLUT4 translocation. Human insulin resistance involves a defect in GLUT4 traffic and targeting leading to accumulation in a dense membrane compartment from which insulin is unable to recruit GLUT4 to the cell surface.
Alternate names: GLUT-4, Glucose transporter 4, Glucose transporter type 4 insulin-responsive, Solute carrier family 2 facilitated glucose transporter member 4
Gene ID 6517
NCBI Accession NP_001033
UniProt P14672
Application Notes Western blot. Immunoprecipitation. Immunohistochemistry on Frozen Sections. Immunohistochemistry on Paraffin Sections: 10-20 µg/ml. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 5.0 mg/mL
Buffer PBS containing 0.09% Sodium Azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Supplier Images
anti-Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 4 (SLC2A4) (C-Term) antibody Staining of paraffin embedded human heart, demonstrating labelling of cardiac myocytes.
Background publications James, Strube, Mueckler: "Molecular cloning and characterization of an insulin-regulatable glucose transporter." in: Nature, Vol. 338, Issue 6210, pp. 83-7, 1989 (PubMed).

Gangal, Magar: "Biological evaluation of crab meat (Scylla-serrata) in the rat." in: The British journal of nutrition, Vol. 21, Issue 1, pp. 1-6 (PubMed).

Durante, Mustard, Park et al.: "Effects of endurance training on activity and expression of AMP-activated protein kinase isoforms in rat muscles." in: American journal of physiology. Endocrinology and metabolism, Vol. 283, Issue 1, pp. E178-86, 2002 (PubMed).

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