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SLC2A4 antibody (Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 4) (C-Term)

Details for Product anti-SLC2A4 Antibody No. ABIN113521, Supplier: Log in to see
Antigen
  • GLUT4
  • SLC2A4
  • Glut-4
  • Glut4
  • glut4
  • slc2a4
  • solute carrier family 2 (facilitated glucose transporter), member 4
  • SLC2A4
  • Slc2a4
  • slc2a4
  • GLUT4
Alternatives
anti-Human SLC2A4 antibody for Immunohistochemistry (Frozen Sections)
Epitope
C-Term
44
16
11
9
8
7
5
4
4
4
3
2
2
2
2
2
1
1
1
1
1
1
1
Reactivity
Human, Monkey, Mouse (Murine), Pig (Porcine), Rat (Rattus)
184
115
94
22
20
20
6
6
4
4
3
2
2
1
1
1
1
1
1
Host
Rabbit
101
89
17
7
Clonality
Polyclonal
Conjugate
This SLC2A4 antibody is un-conjugated
10
7
5
4
4
4
4
4
3
3
3
3
3
2
2
2
2
1
1
1
1
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Western Blotting (WB)
191
101
83
50
39
34
30
27
19
3
2
2
2
2
1
1
1
1
1
Options
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Immunogen A 12 amino acid peptide corresponding to the carboxyl terminus of the insulin regulatable glucose transporter conjugated to Keyhole Limpet Hemocyanin.
Specificity This antibody recognizes Glucose Transporter 4 (GLUT4). It does not react with HEP G2 type Glucose Transporter in Human erythrocytes, Rat brain or other tissues that do not exhibit sensitivity to Insulin. Reacts with Monkey, Pig, Mouse and Rat.
Purification Affinity Chromatography.
Alternative Name GLUT4 / SLC2A4 (SLC2A4 Antibody Abstract)
Background GLUT4 is the insulin-regulated glucose transporter found in adipose tissue and striated muscle, responsible for glucose disposal. The stimulation of glucose uptake by insulin requires translocation of the GLUT4 glucose transporter from intracellular storage sites to the cell surface. Activation of phosphatidylinositol-3-OH kinase (PI3K) is required for this trafficking event, but it is not sufficient to produce GLUT4 translocation. Human insulin resistance involves a defect in GLUT4 traffic and targeting leading to accumulation in a dense membrane compartment from which insulin is unable to recruit GLUT4 to the cell surface.Synonyms: GLUT-4, Glucose transporter 4, Glucose transporter type 4 insulin-responsive, Solute carrier family 2 facilitated glucose transporter member 4
Gene ID 6517
NCBI Accession NP_001033
UniProt P14672
Pathways AMPK Signaling, Carbohydrate Homeostasis
Application Notes Western blot. Immunoprecipitation. Immunohistochemistry on Frozen Sections. Immunohistochemistry on Paraffin Sections: 10-20 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 5.0 mg/mL
Buffer PBS containing 0.09 % Sodium Azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Immunohistochemistry (IHC) image for anti-SLC2A4 antibody (Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 4) (C-Term) (ABIN113521) Staining of paraffin embedded human heart, demonstrating labelling of cardiac myocytes.
Background publications Durante, Mustard, Park, Winder, Hardie: "Effects of endurance training on activity and expression of AMP-activated protein kinase isoforms in rat muscles." in: American journal of physiology. Endocrinology and metabolism, Vol. 283, Issue 1, pp. E178-86, 2002 (PubMed).

James, Strube, Mueckler: "Molecular cloning and characterization of an insulin-regulatable glucose transporter." in: Nature, Vol. 338, Issue 6210, pp. 83-7, 1989 (PubMed).

Gangal, Magar: "Biological evaluation of crab meat (Scylla-serrata) in the rat." in: The British journal of nutrition, Vol. 21, Issue 1, pp. 1-6, 1970 (PubMed).

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