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Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 4 (SLC2A4) (C-Term) antibody

Details for Product No. ABIN113523
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Antigen
Synonyms GLUT4, SLC2A4, Glut-4, Glut4, glut4, slc2a4
Epitope
C-Term
(17), (9), (5), (4), (4), (3), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Monkey, Mouse (Murine), Pig (Porcine), Rat (Rattus)
(76), (46), (43), (17), (14), (13), (3), (2), (1), (1), (1), (1)
Host
Sheep
(58), (28), (4), (3)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunoprecipitation (IP), Western Blotting (WB)
(74), (35), (22), (21), (17), (11), (10), (8), (7), (5), (2), (2), (1)
Pubmed 1 reference available
Quantity 0.1 mL
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Catalog No. ABIN113523
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Immunogen 12 amino acid peptide specific for the carboxy terminus of the insulin regulatable glucose transporter. A cysteine was included at the N-terminus to accommodate protein conjugation.
Specificity Reacts with IRGT in rat heart plasma membranes. 2 major bands are detected at 65 kD and 43 kD. The 43 kD band is 80 % blocked by the peptide at 0.5 µg/ml. The 65 kD band (non specific) is not blocked by peptide at this concentration.
Purification Serum
Alternative Name GLUT4 / SLC2A4
Background The stimulation of glucose uptake by insulin in muscle and adipose tissue requires translocation of the GLUT4 glucose transporter from intracellular storage sites to the cell surface. Activation of phosphatidylinositol-3-OH kinase (PI3K) is required for this trafficking event, but it is not sufficient to produce GLUT4 translocation. Human insulin resistance involves a defect in GLUT4 traffic and targeting leading to accumulation in a dense membrane compartment from which insulin is unable to recruit GLUT4 to the cell surface.
Alternate names: GLUT-4, Glucose transporter 4, Glucose transporter type 4 insulin-responsive, Solute carrier family 2 facilitated glucose transporter member 4
Gene ID 6517
NCBI Accession NP_001033.1
UniProt P14672
Application Notes Immunoprecipitation. Western blot (has been used at 1/1000 in blotting of rat heart plasma membranes with20-30 g protein/lane. Immunoblotting. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Handling Advice Dilute only prior to immediate use
Storage 4 °C
Storage Comment Store the antibody (undiluted) at 2-8°C. DO NOT FREEZE! Freezing alkaline phosphatase conjugates will result in a substantial loss of enzymatic activity.
Expiry Date 12 months
Background publications James, Strube, Mueckler: "Molecular cloning and characterization of an insulin-regulatable glucose transporter." in: Nature, Vol. 338, Issue 6210, pp. 83-7, 1989 (PubMed).

Validation Images
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