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CD72 Molecule (CD72) antibody (FITC)

Details for Product No. ABIN114245, Supplier: Log in to see
Antigen
  • CD72c
  • Ly-19
  • Ly-32
  • Ly-m19
  • Lyb-2
  • CD72b
  • LYB2
Reactivity
Mouse (Murine)
99
32
7
Host
Mouse
77
53
1
1
Clonality (Clone)
Monoclonal ()
Conjugate
FITC
17
15
12
3
3
3
1
Application
Flow Cytometry (FACS)
55
52
46
19
10
7
3
3
2
2
2
1
Supplier
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Clone CT-72-4
Isotype IgG2b
Specificity This monoclonal antibody reacts with an antigen that is expressed on pre B and B cells with either Lyb-2a or Lyb-2b allele. It is also found on some T cell subsets and a small percentage of thymocytes.
Alternative Name CD72 (CD72 Antibody Abstract)
Background CD72 antigen is a member of the type II integral membrane glycoproteins which includes other related cell surface molecules such as the asialoglycoprotein receptors, CD23 and the Kupffer cell receptor. The function of CD72 is unknown but the exposure of B cells to CD72 antibodies activates a variety of signaling pathways and can induce MHC class II expression and B cell proliferation. CD72 antigen is expressed on all cells of B cell lineage with the exception of plasma cells and weakly on human tissue macrophages.Synonyms: B-Cell marker, B-cell differentiation antigen CD72, Ly-32, Ly32, Lyb-2, Lymphocyte antigen 32
Gene ID 100504743
NCBI Accession XP_003086403
UniProt P21855
Research Area Stem Cells, Hematopoietic Progenitors, Adaptive Immunity, CD Antigens, Surface Receptors of Immune Cells
Pathways
Application Notes Flow Cytometry: single, dual or three colour, 1g is the maximum amount of antibodyrequired for 10^6 cells, Lesser amounts of antibody may be sufficient, and it isrecommended that the customer determine the optimum amount of antibody for eachapplication.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0.1 mg/mL
Buffer PBS, 0.1 % NaN3 and EIA grade BSA as a stabilizing protein to bring total protein concentration to 4-5 mg/mL.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Flow Cytometry (FACS) image for anti-CD72 Molecule (CD72) antibody (FITC) (ABIN114245) Cell source: C57BL/6 spleen cells - Percentage of cells stained above control: 99.7%
Background publications Schimmel, Kearley, Nijkamp et al.: "Hydrogen adsorption in carbon nanostructures: comparison of nanotubes, fibers, and coals." in: Chemistry (Weinheim an der Bergstrasse, Germany), Vol. 9, Issue 19, pp. 4764-70, 2003 (PubMed).

Robinson, Landolfi, Schäfer et al.: "Biochemical identity of the mouse Ly-19.2 and Ly-32.2 alloantigens with the B cell differentiation antigen Lyb-2/CD72." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 151, Issue 9, pp. 4764-72, 1993 (PubMed).

Luo, Van de Velde, von Hoegen et al.: "Ly-1 (CD5), a membrane glycoprotein of mouse T lymphocytes and a subset of B cells, is a natural ligand of the B cell surface protein Lyb-2 (CD72)." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 148, Issue 6, pp. 1630-4, 1992 (PubMed).