Melanoma antibody

Details for Product No. ABIN114489
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Clonality (Clone)
Monoclonal ()
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(15), (11), (3), (3), (1), (1), (1), (1)
Pubmed 3 references available
Catalog no. ABIN114489
Quantity 0.5 mL
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Immunogen BALB/C mice were injected with extract of pigmented melanoma metastases from lymph nodes.
Clone HMB 45
Isotype IgG1
Specificity This antibody reacts with a neuraminidase sensitive oligosaccharide side chain of a glycoconjugate present in immature melanosomes. It reacts with junctional and blue nevus cells. Non-melanocytic cells are negative. Cellular Localization: Cytoplasm.
Purification Supernatant
Background Alternate names: Melanoma marker
Research Area Cancer
Application Notes Western Blot. Formalin fixed Paraffin Embedded Tissue: 1/25-1/50 in an ABC method for 30 minutes atroom temperature. Positive Control: Melanoma. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Supplier Images
anti-Melanoma antibody Formalin fixed paraffin embedded human melanoma stained with Melanoma antibody
General Kapur, Bigler, Skelly et al.: "Anti-melanoma monoclonal antibody HMB45 identifies an oncofetal glycoconjugate associated with immature melanosomes." in: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, Vol. 40, Issue 2, pp. 207-12, 1992 (PubMed).

Gown, Vogel, Hoak et al.: "Monoclonal antibodies specific for melanocytic tumors distinguish subpopulations of melanocytes." in: The American journal of pathology, Vol. 123, Issue 2, pp. 195-203, 1986 (PubMed).

Lee, Guo, Lim et al.: "Clinical and molecular characteristics of hereditary non-polyposis colorectal cancer families in Southeast Asia." in: Clinical genetics, Vol. 68, Issue 2, pp. 137-45, 2005 (PubMed).

Hosts (25)
Reactivities (23)
Applications (15), (11), (3), (3), (1), (1), (1), (1)
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