Carbohydrate Antigen 19-9 (CA19-9) antibody

Antigen: Carbohydrate Antigen 19-9 (CA19-9)

Clonality: Monoclonal (C241:5:1:4)

Host: Mouse

Reactivity: Human

Application: Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Catalog no.: ABIN114575

Additional Information

Characteristics: Synonyms: CA19-9, Sialyl Lewis a, Sialosyl Lewis a

Alternative name: CA 19-9

Immunogen: Human colorectal adenocarcinoma cell line COLO 205.

Format: Supernatant

Isotype: IgG1

Clone: C241:5:1:4

Description: CA 19-9 has been shown to be useful marker in the diagnosis and management ofgastrointestinal cancers.

Specificity: This antibody reacts specifically with Sialyl Lewis a and recognize an epitope beingdesignated CA 19-9. It does not cross reacts with Lewis a and Lewis b. Cellular Localization: CytoplasmicSpecies: Human. Others not tested.

Application Details

Application Notes: Immunohistochemistry on paraffin embedded sections: diluted of 1: 25-1: 50 in an ABCmethod (30 minutes at room temperature)Positive Control: Colon carcinomaOther applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.

Buffer: 10 mM citrate buffer, pH 6.0

Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Research Area: Cancer, Cell/Tissue Markers, Blood Components

Restrictions: For Research Use only

Publications

Publications: Johansson, Nilsson, Baeckstroem et al.: "Novel epitopes on the CA50-carrying antigen: chemical and immunochemical studies." in: Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, Vol. 12, Issue 3, pp. 159-70, 1991 (PubMed).

Kuusela, Haglund, Roberts: "Comparison of a new tumour marker CA 242 with CA 19-9, CA 50 and carcinoembryonic antigen (CEA) in digestive tract diseases." in: British journal of cancer, Vol. 63, Issue 4, pp. 636-40, 1991 (PubMed).

Haglund, Lindgren, Roberts et al.: "Tissue expression of the tumour associated antigen CA242 in benign and malignant pancreatic lesions. A comparison with CA 50 and CA 19-9." in: British journal of cancer, Vol. 60, Issue 6, pp. 845-51, 1990 (PubMed).