Integrin beta 3 antibody (ITGB3)

Details for Product anti-ITGB3 Antibody No. ABIN114660, Supplier: Log in to see
Antigen
  • CD61
  • GP3A
  • INGRB3
  • BDPLT16
  • BDPLT2
  • GPIIIa
  • GT
  • INTB3
  • integrin
  • GPIIIA
  • integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
  • integrin beta 3
  • integrin, beta 3
  • ITGB3
  • Itgb3
Alternatives
anti-Human Integrin beta 3 antibody for Biochemical Assay
Reactivity
Human
584
240
203
28
27
25
24
19
16
13
6
5
4
4
4
3
2
2
2
2
2
2
1
1
1
1
Host
Mouse
368
231
52
29
19
2
1
Clonality (Clone)
Monoclonal ()
Conjugate
This Integrin beta 3 antibody is un-conjugated
78
53
26
20
16
13
12
11
11
10
9
7
7
7
7
6
6
6
6
6
6
5
2
2
2
2
2
2
2
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
419
274
163
135
111
91
80
75
64
27
13
13
8
6
6
5
5
4
2
2
2
2
1
1
1
Options
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Immunogen BALB/C mice were immunized with PHA-stimulated human mononuclear cells.
Clone Y2-51
Isotype IgG1
Purification Supernatant
Alternative Name CD61 / ITGB3 (ITGB3 Antibody Abstract)
Background The glycoprotein IIIa molecule produced by endothelium cells is identical in sequence to platelet glycoprotein IIIa.Synonyms: GP3A, GPIIIa, Integrin beta-3, Platelet membrane glycoprotein IIIa
Gene ID 9606
UniProt P05106
Research Area CD Antigens, Surface Receptors of Immune Cells
Pathways Regulation of G-Protein Coupled Receptor Protein Signaling, Signaling Events mediated by VEGFR1 and VEGFR2, Smooth Muscle Cell Migration, Integrin Complex
Application Notes Immunohistochemistry on formalin-fixed paraffin embedded sections: diluted of 1: 25-1: 50in an ABC method (30 minutes at room temperature)This antibody is not compatible with Zenker and B5 fixed tissues. Recommended Positive Control: Tonsil
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer containing azide as the preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Immunohistochemistry (IHC) image for anti-Integrin beta 3 antibody (ITGB3) (ABIN114660) Formalin fixed paraffin embedded human bone marrow stained with CD61 antibody ABIN114659
Product cited in: Skaik, Battermann, Hiller, Meyer, Figueiredo, Salama, Blasczyk: "Development of a single-antigen magnetic bead assay (SAMBA) for the sensitive detection of HPA-1a alloantibodies using tag-engineered recombinant soluble β3 integrin." in: Journal of immunological methods, Vol. 391, Issue 1-2, pp. 72-80, 2013 (PubMed).

Background publications Gatter, Cordell, Turley, Heryet, Kieffer, Anstee, Mason: "The immunohistological detection of platelets, megakaryocytes and thrombi in routinely processed specimens." in: Histopathology, Vol. 13, Issue 3, pp. 257-67, 1989 (PubMed).

Kanz, Mielke, Fauser: "Analysis of human hemopoietic progenitor cells for the expression of glycoprotein IIIa." in: Experimental hematology, Vol. 16, Issue 9, pp. 741-7, 1988 (PubMed).

Zimrin, Eisman, Vilaire, Schwartz, Bennett, Poncz: "Structure of platelet glycoprotein IIIa. A common subunit for two different membrane receptors." in: The Journal of clinical investigation, Vol. 81, Issue 5, pp. 1470-5, 1988 (PubMed).