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Estrogen Receptor alpha antibody (Estrogen Receptor 1)

Details for Product anti-ESR1 Antibody No. ABIN114680, Supplier: Login to see New
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(865), (290), (168), (31), (15), (11), (11), (7), (6), (4), (3), (2), (2), (1), (1)
(660), (247), (10), (3), (3)
Clonality (Clone)
Monoclonal ()
This Estrogen Receptor alpha antibody is un-conjugated
(35), (31), (28), (15), (14), (14), (10), (8), (8), (8), (8), (8), (8), (8), (8)
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(661), (275), (274), (194), (128), (92), (85), (41), (32), (18), (15), (10), (9), (8), (4), (4), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Pubmed 4 references available
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Quantity 1 mL
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Immunogen Recombinant human estrogen receptor protein.
Clone 1D5
Isotype IgG1
Specificity This antibody is specific to estrogen receptor, which is associated with superior prognosis and a better response to endocrine therapy.
Cellular Localization: Nuclear
Purification Supernatant
Alternative Name Estrogen Receptor alpha (ESR1 Antibody Abstract)
Background The nuclei of the estrogen receptor positive cells stain very strongly with this antibody, without any staining in the cytoplasm. However, on cryostat sections a positive staining of estrogen receptor in the nucleus as well as cytoplasm can be seen.Synonyms: ER alpha, ESR, ESR1, Estradiol receptor, NR3A1, Nuclear receptor subfamily 3 group A member 1
Gene ID 2099
NCBI Accession NP_000116
UniProt P03372
Research Area Cancer, Endocrine system, Transcription Factors, Hormones, Receptors
Pathways Nuclear Receptor Transcription Pathway, EGFR Signaling Pathway, Retinoic Acid Receptor Signaling Pathway
Application Notes Western Blotting: 1: 50 to 1: 100. Immunohistochemistry on frozen and paraffin embedded sections: diluted of 1: 25 to 1: 50 inan ABC method (30 minutes at room temperature)Recommended Positive Control: Breast carcinoma
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer 10 mM citrate buffer, pH 6.0 - containing sodium azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Immunohistochemistry (IHC) image for anti-Estrogen Receptor alpha antibody (Estrogen Receptor 1) (ABIN114680) Formalin fixed paraffin embedded human breast carcinoma stained with Estrogen Recepto...
Background publications Kumar, Green, Stack et al.: "Functional domains of the human estrogen receptor." in: Cell, Vol. 51, Issue 6, pp. 941-51, 1988 (PubMed).

Pertschuk, Kim, Nayer et al.: "Immunocytochemical estrogen and progestin receptor assays in breast cancer with monoclonal antibodies. Histopathologic, demographic, and biochemical correlations and relationship to endocrine response and survival." in: Cancer, Vol. 66, Issue 8, pp. 1663-70, 1990 (PubMed).

Graham, Jin, Lloyd: "Detection of estrogen receptor in paraffin-embedded sections of breast carcinoma by immunohistochemistry and in situ hybridization." in: The American journal of surgical pathology, Vol. 15, Issue 5, pp. 475-85, 1991 (PubMed).

Bur, Zimarowski, Schnitt et al.: "Estrogen receptor immunohistochemistry in carcinoma in situ of the breast." in: Cancer, Vol. 69, Issue 5, pp. 1174-81, 1992 (PubMed).

Catalog No. ABIN114680

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