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Tumor Necrosis Factor Receptor Superfamily, Member 11b (TNFRSF11B) (AA 21-39), (N-Term) antibody

Details for Product No. ABIN114693, Supplier: Log in to see
Antigen
  • ocif
  • opg
  • tr1
  • OCIF
  • OPG
  • TR1
  • Opg
  • tumor necrosis factor receptor superfamily, member 11b
  • osteoprotegerin
  • tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)
  • TNFRSF11B
  • tnfrsf11b
  • LOC100037695
  • Tnfrsf11b
Epitope
N-Term, AA 21-39
26
8
7
7
5
3
2
2
1
1
1
1
1
1
1
1
Reactivity
Human
119
31
13
2
2
1
1
1
1
Host
Mouse
65
44
7
2
1
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
10
4
4
4
3
3
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
105
55
45
37
33
29
25
18
13
11
2
1
1
Options
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Immunogen Synthetic OPG peptide that comprises AA21 to AA39 homologous with human osteoprotegerin (N-terminal C has been added to the peptide)
Clone OPG-13
Isotype IgG1
Specificity The Anti Human Osteoprotegerin, Clone: OPG-13 is a mouse monoclonal antibody against synthetic peptide of Human Osteoprotegerin.
Purification Affinity chromatography on protein G
Alternative Name Osteoprotegerin / TNFRSF11B (TNFRSF11B Antibody Abstract)
Background Osteoprotegerin (OPG) or osteoclastogenesis inhibitory factor (OCIF) is a secretory glycoprotein belonging to TNF receptor superfamily. OPG consists of 401 amino acid residues, it has a molecular weight of 60 kDa as a monomer and 120 kDa as a disulfide-linked dimer and is produced in different tissues, e.g. bone, skin, liver, stomach, intestine and lung. Osteoprotegerin inhibits the recruitment, proliferation and activation of osteoclasts. Osteoclast formation activity may be monitored principally by determination of concentration ratio of osteoprotegerin ligand (OPGL)/OPG. Alteration of this ratio may be the cause of bone loss in many imbalances in bone metabolism such as osteoporosis, osteopetrosis, hypercalcemia, metastatic osteolytic lesions and rheumatic bone degradation.Synonyms: OCIF, OPG, Osteoclastogenesis inhibitory factor, Tumor necrosis factor receptor superfamily member 11B
Gene ID 4982
NCBI Accession NP_002537
UniProt O00300
Application Notes ELISA. Western Blot.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Reconstitution Restore with 0.1 mL of deionized water
Concentration 1.0 mg/mL
Buffer 0.05 M phosphate buffer, 0.1 M NaCl, pH 7.2. AZIDE FREE
Preservative Azide free
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Prior to reconstitution store at -70 °C. Following reconstitution store the antibody (in aliquots) at -20 °C for 6 month.
Expiry Date 6 months
Background publications Bolten, Weissbach, Kaden: "[Cryopreserved human sperm deposits: usability after decades of storage]" in: Der Urologe. Ausg. A, Vol. 44, Issue 8, pp. 904-8, 2005 (PubMed).

Yasuda, Shima, Nakagawa, Mochizuki, Yano, Fujise, Sato, Goto, Yamaguchi, Kuriyama, Kanno, Murakami, Tsuda, Morinaga, Higashio: "Identity of osteoclastogenesis inhibitory factor (OCIF) and osteoprotegerin (OPG): a mechanism by which OPG/OCIF inhibits osteoclastogenesis in vitro." in: Endocrinology, Vol. 139, Issue 3, pp. 1329-37, 1998 (PubMed).

Simonet, Lacey, Dunstan, Kelley, Chang, Lüthy, Nguyen, Wooden, Bennett, Boone, Shimamoto, DeRose, Elliott, Colombero, Tan, Trail, Sullivan, Davy, Bucay, Renshaw-Gegg, Hughes, Hill, Pattison, Campbell et al.: "Osteoprotegerin: a novel secreted protein involved in the regulation of bone density. ..." in: Cell, Vol. 89, Issue 2, pp. 309-19, 1997 (PubMed).

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