Ubiquitin antibody

Details for Product No. ABIN114741
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Antigen
Synonyms
CG11624, DmUb, DmUbi-p63E, Dmel\\CG11624, Ub, Ubi-P63e, Ubi-p, Ubi63E, Ubi63p, Ubip, Ubiq, Ubp, ubi, ubi-p63E, ubi63E, CG18282, CG32744, CR32744, DmUbi-p5E, Dmel\\CG32744, ubiquitin, si:dz180g5.5, si: ... show more
CG11624, DmUb, DmUbi-p63E, Dmel\\CG11624, Ub, Ubi-P63e, Ubi-p, Ubi63E, Ubi63p, Ubip, Ubiq, Ubp, ubi, ubi-p63E, ubi63E, CG18282, CG32744, CR32744, DmUbi-p5E, Dmel\\CG32744, ubiquitin, si:dz180g5.5, si:busm1-180g5.5, LOC100194618, UBIQ, Ubiquitin, LOC100282068 show less
Reactivity
Human
(148), (109), (55), (55), (15), (12), (9), (8), (6), (6), (6), (6), (4), (4), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1)
Host
Mouse
(136), (115), (3), (2), (2), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(9), (6), (5), (5), (4), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(182), (126), (81), (65), (36), (32), (24), (23), (12), (10), (2), (1)
Pubmed 3 references available
Quantity 1 mL
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Catalog No. ABIN114741
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Immunogen BALB/C mice were immunized with purified human ubiquitin.
Clone FPM1
Isotype IgG1
Specificity This antibody recognizes neurofibrillary tangles in Alzheimer’s disease, Lewy bodies in Lewy body disease, Rosenthal fibers in astrocytomas and Mallory bodies in alcoholic liver disease. It stains dot-like structures in the white matter of normal aging brain. Cellular Localization: Nuclear, cytoplasmic and cell membrane
Purification Supernatant
Background Alternate names: Polyubiquitin-B, UBB
Gene ID 7314
UniProt P0CG47
Research Area Neurology, Proteolysis / Ubiquitin, Alzheimer's Disease, Proteases, Amino Acids
Application Notes Immunohistochemistry on formalin fixed, paraffin embedded sections: diluted of 1: 10-1: 25in an ABC method (30 minutes at room temperature)Recommended Positive Control: Alzheimer brainOther applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer containing azide as the preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Lowe, Lennox, Jefferson et al.: "A filamentous inclusion body within anterior horn neurones in motor neurone disease defined by immunocytochemical localisation of ubiquitin." in: Neuroscience letters, Vol. 94, Issue 1-2, pp. 203-10, 1989 (PubMed).

General Lennox, Lowe, Morrell et al.: "Anti-ubiquitin immunocytochemistry is more sensitive than conventional techniques in the detection of diffuse Lewy body disease." in: Journal of neurology, neurosurgery, and psychiatry, Vol. 52, Issue 1, pp. 67-71, 1989 (PubMed).

Lowe, Blanchard, Morrell et al.: "Ubiquitin is a common factor in intermediate filament inclusion bodies of diverse type in man, including those of Parkinson's disease, Pick's disease, and Alzheimer's disease, as well as Rosenthal fibres in cerebellar astrocytomas, cytoplasmic bodies in m" in: The Journal of pathology, Vol. 155, Issue 1, pp. 9-15, 1988 (PubMed).

Validation Images
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