Cadherin (C-Term) antibody

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Antigen
  • PCDH10
  • OLpcad
  • cadherin
  • ci-cadherin
  • protocadherin 10
  • cadherin
  • PCDH10
  • ci-cadherin
  • LOC430062
Epitope
C-Term
30
8
1
1
1
1
1
1
Reactivity
Human, Mammalian
39
33
32
28
12
11
11
11
9
5
3
3
2
2
1
1
1
1
1
1
1
Host
Mouse
36
13
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
1
1
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
35
26
21
9
9
3
3
3
1
Options
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Immunogen Synthetic peptide corresponding to the C-terminal amino acids of chicken N-Cadherin with extra N-terminal lysine residue.
Clone CH-19
Isotype IgG1
Purification Supernatant
Background Cadherins are members of a multigene family of single chain glycoprotein receptors mediating Ca2+ dependent cell-cell adhesion.Synonyms: pan Cadherin
Research Area Extracellular Matrix, Signaling, Cytoskeleton
Application Notes Immunohistochemistry on formalin-fixed paraffin embedded sections: diluted to a titer of1: 25-1: 50 in an ABC method (30 minutes at room temperature)Recommended Positive Control: TonsilProteolytic treatment prior to immunostaining is required.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer containing sodium azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Background publications Grunwald: "The structural and functional analysis of cadherin calcium-dependent cell adhesion molecules." in: Current opinion in cell biology, Vol. 5, Issue 5, pp. 797-805, 1993 (PubMed).

Geiger, Volberg, Ginsberg, Bitzur, Sabanay, Hynes: "Broad spectrum pan-cadherin antibodies, reactive with the C-terminal 24 amino acid residues of N-cadherin." in: Journal of cell science, Vol. 97 ( Pt 4), pp. 607-14, 1991 (PubMed).

Takeichi: "The cadherins: cell-cell adhesion molecules controlling animal morphogenesis." in: Development (Cambridge, England), Vol. 102, Issue 4, pp. 639-55, 1988 (PubMed).