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KI-67 antibody (Antigen Identified By Monoclonal antibody Ki-67)

Details for Product anti-MKI67 Antibody No. ABIN114756, Supplier: Login to see New
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(373), (65), (37), (27), (11), (11), (5), (3)
(177), (144), (44), (12), (3)
Clonality (Clone)
Monoclonal ()
This KI-67 antibody is un-conjugated
(12), (8), (7), (7), (5), (5), (4), (4), (4), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(131), (118), (116), (86), (65), (39), (39), (35), (18), (10), (10), (6), (6), (3), (3), (3), (2), (1), (1), (1)
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Catalog number from supplier Login to see New
Quantity 1 mL
Shipping to United States ( )
Immunogen Prokaryotic recombinant protein corresponding to a 1086 bp of Ki-67 motif containing cDNA fragment.
Clone MM1
Isotype IgG1
Specificity This antibody is specific to Ki-67 nuclear antigen expressed on all proliferating cells during late G1, S, M and G2 phase of the cell cycle. Ki-67 antibody is useful in establishing the growth fraction of neoplasms by identifying Ki-67 positive cells. Among low grade lymphomas, a Ki-67 value greater than 20-25 % has been shown to identify patients with a more aggressive course and among intermediate to high grade lymphomas, poorer survival has been shown with Ki-67 index exceeding 60 %.
Cellular Localization:Nuclear
Purification Supernatant
Alternative Name Ki-67 (MKI67 Antibody Abstract)
Background Ki-67 is a nuclear protein that is expressed in proliferating cells and may be required for maintaining cell proliferation. Ki-67 has been used as a marker for cell proliferation of solid tumors and some hematological malignancies. A correlation has been demonstrated between Ki-67 index and the histopathological grade of neoplasms. Assessment of Ki-67 expression in renal and ureter tumors shows a correlation between tumor proliferation and disease progression, thus making it possible to differentiate high-risk patients. Ki-67 expression may also prove to be important for distinguishing between malignant and benign peripheral nerve sheath tumors.Synonyms: Ki67 antigen, MKI67, Proliferation marker
Gene ID 4288
NCBI Accession NP_001139438
UniProt P46013
Research Area Proliferation Markers, Cell Cycle
Application Notes Immunohistochemistry on Formalin-Fixid Paraffin Embedded Sections: Use at 1/25-1/75 inan ABC method for 30 minutes at RT. Paraffin-embedded tissue sections require high temperature antigen unmasking using 10 mM citrate buffer, pH 6.0. Recommended Positive Control: Tonsil.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8 °C.
Catalog No. ABIN114756

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