Antigen Identified By Monoclonal Antibody Ki-67 (MKI67) antibody

Details for Product No. ABIN114756
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Antigen
Synonyms MKI67, kia, mki67, MGC132156, D630048A14Rik, Ki-67, Ki67, KIA, MIB-1
Reactivity
Human
(200), (30), (28), (2), (1), (1)
Host
Mouse
(125), (75), (6), (2), (2)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(94), (68), (63), (58), (35), (29), (18), (10), (9), (1), (1)
Quantity 1 mL
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Request Want additional data for this product?

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Catalog No. ABIN114756
731.50 $
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  • +1 404 474 4654
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Immunogen Prokaryotic recombinant protein corresponding to a 1086 bp of Ki-67 motif containing cDNA fragment.
Clone MM1
Isotype IgG1
Specificity This antibody is specific to Ki-67 nuclear antigen expressed on all proliferating cells during late G1, S, M and G2 phase of the cell cycle. Ki-67 antibody is useful in establishing the growth fraction of neoplasms by identifying Ki-67 positive cells. Among low grade lymphomas, a Ki-67 value greater than 20-25% has been shown to identify patients with a more aggressive course and among intermediate to high grade lymphomas, poorer survival has been shown with Ki-67 index exceeding 60%. Cellular Localization: Nuclear
Purification Supernatant
Alternative Name Ki-67
Background Ki-67 is a nuclear protein that is expressed in proliferating cells and may be required for maintaining cell proliferation. Ki-67 has been used as a marker for cell proliferation of solid tumors and some hematological malignancies. A correlation has been demonstrated between Ki-67 index and the histopathological grade of neoplasms. Assessment of Ki-67 expression in renal and ureter tumors shows a correlation between tumor proliferation and disease progression, thus making it possible to differentiate high-risk patients. Ki-67 expression may also prove to be important for distinguishing between malignant and benign peripheral nerve sheath tumors.
Alternate names: Ki67 antigen, MKI67, Proliferation marker
Gene ID 4288
NCBI Accession NP_001139438
UniProt P46013
Research Area Proliferation Markers, Cell Cycle
Application Notes Immunohistochemistry on Formalin-Fixid Paraffin Embedded Sections: Use at 1/25-1/75 inan ABC method for 30 minutes at RT. Paraffin-embedded tissue sections require high temperature antigen unmasking using 10mM citrate buffer, pH 6.0. Recommended Positive Control: Tonsil. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8°C.
Expiry Date 12 months
Validation Images
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