Ret Proto-Oncogene antibody (RET) (C-Term)

Details for Product anti-RET Antibody No. ABIN115113, Supplier: Log in to see
Antigen
  • c-ret
  • cret
  • etID315074.13
  • ret1
  • wu:fd13h01
  • X-ret
  • ret-A
  • xret
  • RET
  • MTC1
  • CDHF12
  • CDHR16
  • HSCR1
  • MEN2A
  • MEN2B
  • PTC
  • RET-ELE1
  • RET51
  • RET9
  • c-Ret
  • ret proto-oncogene receptor tyrosine kinase
  • ret proto-oncogene
  • ret
  • RET
  • Ret
Alternatives
anti-Human Ret Proto-Oncogene antibody for Immunohistochemistry (Paraffin-embedded Sections)
Epitope
C-Term
52
41
30
28
25
22
22
15
14
14
12
11
8
8
8
8
8
8
6
5
4
4
4
4
3
3
3
3
3
3
3
2
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
395
117
107
9
3
2
2
2
2
1
1
1
1
1
1
1
Host
Mouse
246
147
5
2
1
1
Clonality (Clone)
Monoclonal ()
Conjugate
This Ret Proto-Oncogene antibody is un-conjugated
17
15
15
12
12
9
9
9
8
8
8
5
5
5
5
5
5
4
4
2
2
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
274
144
93
82
65
61
27
8
6
5
4
4
3
3
1
1
Options
Supplier
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Supplier Product No.
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Immunogen BALB/C mice were injected with recombinant protein encoding the extreme C-terminal cytoplasmic region of the human ret oncoprotein.
Clone RET01
Isotype IgG1
Specificity Reacts to Ret Oncoprotein.
Cellular Localization: Cytoplasmic.
Purification Purified
Alternative Name RET (RET Antibody Abstract)
Background Ret proto-oncogene encodes a cell surface glycoprotein belonging to a member of the receptor tyrosine kinase family and is located on chromosome 10q11.2. Ret is observed in several regions of the central nervous system, in the developing cranial nerve ganglia and a subset of cells within dorsal root ganglia, in motor neurons in the spinal cord and hindbrain.Synonyms: C-ret, CDHF12, Cadherin family member 12, Proto-oncogene tyrosine-protein kinase receptor ret
Gene ID 5979
NCBI Accession NP_065681
UniProt P07949
Research Area Signaling, Kinases/Phosphatases
Pathways RTK Signaling, Dopaminergic Neurogenesis, Regulation of Cell Size, Tube Formation
Application Notes Immunohistochemistry on paraffin embedded sections: diluted of 1: 10-1: 20 in an ABC method (90 minutes at room temperature), requires hightemperature antigen unmasking with 10 mM citrate buffer, pH 6.0 prior to immunostaining. Recommended Positive Control: Small intestine.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer Sodium azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Immunohistochemistry (IHC) image for anti-Ret Proto-Oncogene (RET) (C-Term) antibody (ABIN115113) Formalin fixed paraffin embedded human small intestine stained with ret oncoprotein a...
Background publications Nosrat, Tomac, Hoffer, Olson: "Cellular and developmental patterns of expression of Ret and glial cell line-derived neurotrophic factor receptor alpha mRNAs." in: Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale, Vol. 115, Issue 3, pp. 410-22, 1997 (PubMed).

Williams, Rooney, Carss, Cummins, Thomas, Williams: "Analysis of the RET proto-oncogene in sporadic parathyroid adenomas." in: The Journal of pathology, Vol. 180, Issue 2, pp. 138-41, 1997 (PubMed).

Nakamura, Ishizaka, Nagao, Hara, Ishikawa: "Expression of the ret proto-oncogene product in human normal and neoplastic tissues of neural crest origin." in: The Journal of pathology, Vol. 172, Issue 3, pp. 255-60, 1994 (PubMed).

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