MutS Homolog 2, Colon Cancer, Nonpolyposis Type 1 (E. Coli) (MSH2) antibody

Details for Product No. ABIN115118
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Antigen
Synonyms FCC1, COCA1, HNPCC, LCFS2, HNPCC1, AI788990, ATMSH2, MUTS homolog 2, wu:fc06b02, wu:fc13e09, zgc:55333
Reactivity
Human
(107), (34), (20), (7), (3), (2), (2), (1), (1), (1), (1), (1)
Host
Mouse
(72), (39), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(65), (42), (33), (31), (21), (11), (10), (7), (7), (5), (3), (2), (2)
Pubmed 4 references available
Catalog no. ABIN115118
Quantity 1 mL
Price
610.50 $   Plus shipping costs $45.00
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Immunogen BALB/C mice were injected with recombinant human MSH2 protein.
Clone 25D12
Isotype IgG1
Specificity This antibody reacts with a 102 kD protein known as MSH2 (Mismatch Repair protein 2). Cellular Localization: Nuclear
Purification Purified
Alternative Name MSH2
Background MSH2 protein is involved in the initial recognition of mismatched nucleotides during the post replication mismatch repair process. Loss of MSH2 function leads to the accumulation of replication errors, which in turn may be responsible for the multiple mutations required for multistage carcinogenesis.
Alternate names: DNA mismatch repair protein Msh2, MutS protein homolog 2
Gene ID 4436
NCBI Accession NP_000242.1
UniProt P43246
Research Area Cancer, DNA/RNA
Application Notes Immunohistochemistry on paraffin embedded sections: diluted of 1: 10-1: 25 in an ABC method (60 minutes at room temperature)Recommended Positive Control: TonsilOther applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer 10 mM citrate buffer, pH 6.0 - containing sodium azide as preservative.
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Palombo, Iaccarino, Nakajima et al.: "hMutSbeta, a heterodimer of hMSH2 and hMSH3, binds to insertion/deletion loops in DNA." in: Current biology : CB, Vol. 6, Issue 9, pp. 1181-4, 1997 (PubMed).

General Kolodner, Hall, Lipford et al.: "Structure of the human MSH2 locus and analysis of two Muir-Torre kindreds for msh2 mutations." in: Genomics, Vol. 24, Issue 3, pp. 516-26, 1995 (PubMed).

Fishel, Lescoe, Rao et al.: "The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer." in: Cell, Vol. 75, Issue 5, pp. 1027-38, 1994 (PubMed).

Maliaka, Chudina, Belev et al.: "CpG dinucleotides in the hMSH2 and hMLH1 genes are hotspots for HNPCC mutations." in: Human genetics, Vol. 97, Issue 2, pp. 251-5, 1996 (PubMed).

Hosts (72), (39), (1)
Reactivities (107), (34), (20), (7), (3), (2), (2), (1), (1), (1), (1), (1)
Applications (65), (42), (33), (31), (21), (11), (10), (7), (7), (5), (3), (2), (2)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (9), (5), (5), (3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1)
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