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MutS Homolog 2, Colon Cancer, Nonpolyposis Type 1 (E. Coli) (MSH2) antibody

Details for Product No. ABIN115118, Supplier: Log in to see
Antigen
  • ATMSH2
  • MUTS homolog 2
  • AI788990
  • wu:fc06b02
  • wu:fc13e09
  • zgc:55333
  • COCA1
  • FCC1
  • HNPCC
  • HNPCC1
  • LCFS2
  • CG7895
  • DROHOXHK4
  • DROHOXNK4
  • DmNK-4
  • Dmel\CG7895
  • HOX
  • NK-4
  • NK-4/msh-2
  • NK4
  • NK4/msh-2
  • NKX2.5
  • TIN
  • Tin
  • msh-2
  • msh2
  • tin/NK4
Alternatives
anti-Human MutS Homolog 2, Colon Cancer, Nonpolyposis Type 1 (E. Coli) antibody for Immunohistochemistry (Paraffin-embedded Sections)
Reactivity
Human
155
42
27
8
5
3
3
2
1
1
1
1
Host
Mouse
106
47
3
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
104
45
45
40
37
21
18
17
11
6
3
2
1
Supplier
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Immunogen BALB/C mice were injected with recombinant human MSH2 protein.
Clone 25D12
Isotype IgG1
Specificity This antibody reacts with a 102 kDa protein known as MSH2 (Mismatch Repair protein 2).
Cellular Localization: Nuclear
Purification Purified
Alternative Name MSH2 (MSH2 Antibody Abstract)
Background MSH2 protein is involved in the initial recognition of mismatched nucleotides during the post replication mismatch repair process. Loss of MSH2 function leads to the accumulation of replication errors, which in turn may be responsible for the multiple mutations required for multistage carcinogenesis.Synonyms: DNA mismatch repair protein Msh2, MutS protein homolog 2
Gene ID 4436
NCBI Accession NP_000242
UniProt P43246
Research Area Cancer, DNA/RNA
Pathways DNA Damage Repair
Application Notes Immunohistochemistry on paraffin embedded sections: diluted of 1: 10-1: 25 in an ABC method (60 minutes at room temperature)Recommended Positive Control: Tonsil
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer 10 mM citrate buffer, pH 6.0 - containing sodium azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Background publications Palombo, Iaccarino, Nakajima et al.: "hMutSbeta, a heterodimer of hMSH2 and hMSH3, binds to insertion/deletion loops in DNA." in: Current biology : CB, Vol. 6, Issue 9, pp. 1181-4, 1997 (PubMed).

Maliaka, Chudina, Belev et al.: "CpG dinucleotides in the hMSH2 and hMLH1 genes are hotspots for HNPCC mutations." in: Human genetics, Vol. 97, Issue 2, pp. 251-5, 1996 (PubMed).

Fishel, Lescoe, Rao et al.: "The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer." in: Cell, Vol. 75, Issue 5, pp. 1027-38, 1994 (PubMed).

Kolodner, Hall, Lipford et al.: "Structure of the human MSH2 locus and analysis of two Muir-Torre kindreds for msh2 mutations." in: Genomics, Vol. 24, Issue 3, pp. 516-26, 1995 (PubMed).