CDK5 antibody (Cyclin-Dependent Kinase 5)

Details for Product anti-CDK5 Antibody No. ABIN115138, Supplier: Log in to see
Antigen
  • PSSALRE
  • AW048668
  • Crk6
  • CDK5
  • CG8203
  • DmCdk5
  • Dmel\\CG8203
  • cdk5
  • zgc:101604
  • cyclin-dependent kinase 5
  • Cyclin-dependent kinase 5
  • cyclin-dependent protein kinase 5
  • CDK5
  • Cdk5
  • cdk5
  • LOC100352775
Alternatives
anti-Rat (Rattus) CDK5 antibody for ELISA
Reactivity
Human, Mouse (Murine), Rat (Rattus)
232
154
150
19
18
16
16
16
13
13
10
9
5
5
3
3
3
2
1
1
1
1
1
1
Host
Mouse
162
78
Clonality (Clone)
Monoclonal ()
Conjugate
This CDK5 antibody is un-conjugated
5
5
2
2
2
2
2
2
2
2
2
2
2
2
Application
Immunofluorescence (IF), Immunoprecipitation (IP), Western Blotting (WB)
204
96
50
48
38
30
26
18
15
5
4
3
2
Options
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Immunogen BALB/C mice were injected with a recombinant cdk5 protein.
Clone DC17-DC34
Isotype IgG1
Specificity This antibody reacts with a 31 kDa protein known as cdk5.
Cellular Localization: Cytoplasmic, nuclear.
Purification Protein G purified immunoglobulin fraction
Alternative Name CDK5 (CDK5 Antibody Abstract)
Background Cdk-5 is expressed in both cycling and noncycling cells and is present in numerous mammalian tissues. Neuronal and muscle cells contain the highest amount of this protein. Cdk5 activity is involved in terminal differentiation of neurons and muscle cells.Synonyms: Cell division protein kinase 5, Cyclin-dependent kinase 5, PSSALRE, Serine/threonine-protein kinase PSSALRE, TPKII catalytic subunit, Tau protein kinase II catalytic subunit
Gene ID 1020
NCBI Accession NP_001157882
UniProt Q00535
Research Area Cell Cycle, Kinases/Phosphatases
Pathways Cell Division Cycle, Regulation of Muscle Cell Differentiation, Synaptic Membrane, Regulation of Cell Size, Skeletal Muscle Fiber Development, Synaptic Vesicle Exocytosis
Application Notes Immunoprecipitation. Immunofuorescence. Western Blot (use at 1: 100). Positive Control: Brain.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer PBS containing sodium azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Do not freeze working dilutions
Background publications Meyerson, Enders, Wu, Su, Gorka, Nelson, Harlow, Tsai: "A family of human cdc2-related protein kinases." in: The EMBO journal, Vol. 11, Issue 8, pp. 2909-17, 1992 (PubMed).

Xiong, Zhang, Beach: "D type cyclins associate with multiple protein kinases and the DNA replication and repair factor PCNA." in: Cell, Vol. 71, Issue 3, pp. 505-14, 1992 (PubMed).

Matsushime, Roussel, Ashmun, Sherr: "Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle." in: Cell, Vol. 65, Issue 4, pp. 701-13, 1991 (PubMed).

Nurse, Bissett: "Gene required in G1 for commitment to cell cycle and in G2 for control of mitosis in fission yeast." in: Nature, Vol. 292, Issue 5823, pp. 558-60, 1981 (PubMed).