Cyclin-Dependent Kinase 5 (CDK5) antibody

Details for Product No. ABIN115138
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Antigen
Synonyms PSSALRE, AW048668, Crk6, CDK5, CG8203, DmCdk5, Dmel\\CG8203, cdk5, zgc:101604
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(161), (91), (80), (30), (19), (18), (12), (9), (5), (4), (3), (3), (2), (1), (1)
Host
Mouse
(126), (51)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1)
Application
Immunocytochemistry (ICC), Immunofluorescence (IF), Immunoprecipitation (IP), Western Blotting (WB)
(150), (79), (39), (39), (29), (23), (20), (19), (9), (5), (4), (1)
Pubmed 4 references available
Quantity 0.5 mL
Shipping to United States (Change)
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Catalog No. ABIN115138
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Immunogen BALB/C mice were injected with a recombinant cdk5 protein.
Clone DC17-DC34
Isotype IgG1
Specificity This antibody reacts with a 31 kD protein known as cdk5. Cellular Localization: Cytoplasmic, nuclear.
Purification Protein G purified immunoglobulin fraction
Alternative Name CDK5
Background Cdk-5 is expressed in both cycling and noncycling cells and is present in numerous mammalian tissues. Neuronal and muscle cells contain the highest amount of this protein. Cdk5 activity is involved in terminal differentiation of neurons and muscle cells.
Alternate names: Cell division protein kinase 5, Cyclin-dependent kinase 5, PSSALRE, Serine/threonine- protein kinase PSSALRE, TPKII catalytic subunit, Tau protein kinase II catalytic subunit
Gene ID 1020
NCBI Accession NP_001157882
UniProt Q00535
Research Area Cell Cycle, Kinases/Phosphatases
Application Notes Immunoprecipitation. Immunofuorescence. Western Blot (use at 1: 100). Positive Control: Brain. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer PBS containing sodium azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody at 2-8°C for one month or (in aliquots) at -20°C for longer. Do not freeze working dilutions
Expiry Date 12 months
Background publications Xiong, Zhang, Beach: "D type cyclins associate with multiple protein kinases and the DNA replication and repair factor PCNA." in: Cell, Vol. 71, Issue 3, pp. 505-14, 1992 (PubMed).

Meyerson, Enders, Wu et al.: "A family of human cdc2-related protein kinases." in: The EMBO journal, Vol. 11, Issue 8, pp. 2909-17, 1992 (PubMed).

Matsushime, Roussel, Ashmun et al.: "Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle." in: Cell, Vol. 65, Issue 4, pp. 701-13, 1991 (PubMed).

Nurse, Bissett: "Gene required in G1 for commitment to cell cycle and in G2 for control of mitosis in fission yeast." in: Nature, Vol. 292, Issue 5823, pp. 558-60, 1981 (PubMed).

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