EPCAM antibody (Epithelial Cell Adhesion Molecule)

Details for Product anti-EPCAM Antibody No. ABIN115233, Supplier: Log in to see
Antigen
  • sb:cb6
  • tacstd
  • wu:fj17g02
  • zgc:110304
  • zgc:77119
  • tacstd1
  • MGC80540
  • EPCAM
  • TACSTD1
  • egp
  • ksa
  • m4s1
  • mk-1
  • cd326
  • egp40
  • mic18
  • trop1
  • ep-cam
  • hegp-2
  • co17-1a
  • ga733-2
  • GP40
  • LEU-9
  • TP41
  • Tp40
  • DIAR5
  • EGP-2
  • EGP314
  • EGP40
  • ESA
  • HNPCC8
  • KS1/4
  • KSA
  • M4S1
  • MIC18
  • MK-1
  • TROP1
  • CD326
  • EGP
  • Egp314
  • Ep-CAM
  • EpCAM1
  • GA733-2
  • Ly74
  • Tacsd1
  • Tacstd1
  • gp40
  • epithelial cell adhesion molecule
  • zgc:110304
  • CD7 molecule
  • epcam
  • EPCAM
  • zgc:110304
  • LOC100229650
  • CD7
  • Epcam
Reactivity
Human
1014
130
79
2
2
2
2
1
1
Host
Mouse
825
213
43
8
Clonality (Clone)
Monoclonal ()
Conjugate
This EPCAM antibody is un-conjugated
51
50
38
28
26
25
23
22
22
22
20
20
20
20
20
20
15
14
12
6
4
4
4
4
4
2
2
2
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
737
675
580
432
265
234
192
103
100
37
14
10
8
6
4
4
4
3
2
2
2
2
2
1
1
1
Options
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Immunogen BALB/C mice were immunized with human breast carcinoma cell line, MCF-7.
Clone Ber-EP4
Isotype IgG1
Specificity Recognizes Human Epithelial Antigen.
Cellular Localization: Cell membrane.
Purification Supernatant
Alternative Name CD326 / EPCAM / TACSTD1 (EPCAM Antibody Abstract)
Background Epithelial antigen is cell surface glycoprotein and is broadly distributed in epithelial cells and displays a highly conserved expression in carcinomas. Epithelial antigen has been know to play an important role as tumor-cell marker in lymph nodes from patients with esophageal carcinoma. Epithelial antigen can be used to distinguish between basal cell and basosquamous carcinomas and squamous cell carcinoma of the skin.Synonyms: Adenocarcinoma-associated antigen, EGP314, Ep-CAM, Epithelial cell adhesion molecule, Epithelial glycoprotein 314, GA733-2, KS 1/4 antigen, KSA, M1S2, M4S1, MIC18, Major gastrointestinal tumor-associated protein GA733-2, TROP1, Trop-1, Tumor-associated calcium signal transducer 1
Gene ID 4072
NCBI Accession NP_002345
UniProt P16422
Research Area Cancer
Application Notes Immunohistochemistry on Formalin-Fixed Paraffin Embedded Sections: Use at 1/50-1/150dilution in an ABC method (30 minutes at RT). Formalin fixed paraffin embedded tissue sections require high temperature antigenunmasking with 10 mM citrate buffer, pH 6.0 prior to immunostaining. Recommended Positive Control: Kidney.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Background publications Hosch, Kraus, Scheunemann, Izbicki, Schneider, Schumacher, Witter, Speicher, Pantel: "Malignant potential and cytogenetic characteristics of occult disseminated tumor cells in esophageal cancer." in: Cancer research, Vol. 60, Issue 24, pp. 6836-40, 2001 (PubMed).

Carella, Deleonardi, DErrico, Salerno, Egarter-Vigl, Seebacher, Donazzan, Grigioni: "Immunohistochemical panels for differentiating epithelial malignant mesothelioma from lung adenocarcinoma: a study with logistic regression analysis." in: The American journal of surgical pathology, Vol. 25, Issue 1, pp. 43-50, 2000 (PubMed).

Beer, Shepherd, Theaker: "Ber EP4 and epithelial membrane antigen aid distinction of basal cell, squamous cell and basosquamous carcinomas of the skin." in: Histopathology, Vol. 37, Issue 3, pp. 218-23, 2000 (PubMed).

Momburg, Moldenhauer, Hämmerling, Möller: "Immunohistochemical study of the expression of a Mr 34,000 human epithelium-specific surface glycoprotein in normal and malignant tissues." in: Cancer research, Vol. 47, Issue 11, pp. 2883-91, 1987 (PubMed).