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Details for Product No. ABIN115233

Epithelial Cell Adhesion Molecule (EPCAM) antibody

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Antigen
Synonyms
DIAR5, EGP-2, EGP314, EGP40, ESA, HNPCC8, KS1/4, KSA, M4S1, MIC18, MK-1, TACSTD1, TROP1, EGP, Ep-CAM, CD326, Egp314, EpCAM1, GA733-2, Ly74, Tacsd1, Tacstd1, gp40, sb:cb6, tacstd, wu:fj17g02, zgc:11030 ... show more
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Pubmed 4 references available
Catalog no. ABIN115233
Quantity 0.5 mL
Price
313.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 8 Business Days
Immunogen BALB/C mice were immunized with human breast carcinoma cell line, MCF-7.
Clone Ber-EP4
Isotype IgG1
Specificity Recognizes Human Epithelial Antigen. Cellular Localization: Cell membrane.
Purification Supernatant
Alternative Name CD326 / EPCAM / TACSTD1
Background Epithelial antigen is cell surface glycoprotein and is broadly distributed in epithelial cells and displays a highly conserved expression in carcinomas. Epithelial antigen has been know to play an important role as tumor-cell marker in lymph nodes from patients with esophageal carcinoma. Epithelial antigen can be used to distinguish between basal cell and basosquamous carcinomas and squamous cell carcinoma of the skin.
Alternate names: Adenocarcinoma-associated antigen, EGP314, Ep-CAM, Epithelial cell adhesion molecule, Epithelial glycoprotein 314, GA733-2, KS 1/4 antigen, KSA, M1S2, M4S1, MIC18, Major gastrointestinal tumor-associated protein GA733-2, TROP1, Trop-1, Tumor-associated calcium signal transducer 1
Gene ID 4072
NCBI Accession NP_002345.2
UniProt P16422
Research Area Cancer
Application Notes Immunohistochemistry on Formalin-Fixed Paraffin Embedded Sections: Use at 1/50-1/150dilution in an ABC method (30 minutes at RT). Formalin fixed paraffin embedded tissue sections require high temperature antigenunmasking with 10 mM citrate buffer, pH 6.0 prior to immunostaining. Recommended Positive Control: Kidney. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Momburg, Moldenhauer, Hämmerling et al.: "Immunohistochemical study of the expression of a Mr 34,000 human epithelium-specific surface glycoprotein in normal and malignant tissues." in: Cancer research, Vol. 47, Issue 11, pp. 2883-91, 1987 (PubMed).

Beer, Shepherd, Theaker: "Ber EP4 and epithelial membrane antigen aid distinction of basal cell, squamous cell and basosquamous carcinomas of the skin." in: Histopathology, Vol. 37, Issue 3, pp. 218-23, 2000 (PubMed).

Carella, Deleonardi, DErrico et al.: "Immunohistochemical panels for differentiating epithelial malignant mesothelioma from lung adenocarcinoma: a study with logistic regression analysis." in: The American journal of surgical pathology, Vol. 25, Issue 1, pp. 43-50, 2000 (PubMed).

Hosch, Kraus, Scheunemann et al.: "Malignant potential and cytogenetic characteristics of occult disseminated tumor cells in esophageal cancer." in: Cancer research, Vol. 60, Issue 24, pp. 6836-40, 2001 (PubMed).

Alternatives for antigen "Epithelial Cell Adhesion Molecule (EPCAM)", type "Antibodies"
Hosts (169), (53), (12)
Reactivities (216), (50), (37), (17), (17), (17), (2)
Applications (124), (116), (82), (42), (37), (35), (34), (33), (32), (20), (13), (5), (5), (3), (3), (2), (2), (1)
Conjugates (17), (7), (7), (4), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1)
Epitopes (5), (5), (4), (4), (2), (2), (2), (2), (1), (1), (1)
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