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Details for Product No. ABIN115239

Amyloid beta (Abeta) antibody

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Synonyms aaa, abeta, abpp, ad1, appi, ctfgamma, cvap, pn2, APP, ABPP
»Alternatives Human
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
»Alternatives Un-conjugated
»Alternatives Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Pubmed 3 references available
Catalog no. ABIN115239
Quantity 0.5 mL
324.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 8 Business Days
Immunogen A synthetic beta-amyloid peptide (1-40) conjugated to KLH
Clone BAM-10
Isotype IgG1
Specificity This antibody reacts with beta-amyloid protein. It stains Amyloid plaques within the cortex, and Amyloid deposits in blood vessels. Beta-amyloid deposits are also detected in Lewy body dementia, Down's syndrome, amyloidosis and in Gram-Parkinson dementia complex. Cellular localization: Cytoplasmic.
Purification Ascites
Alternative Name Amyloid beta
Background The presence of a large number of neuritic plaques (senile) and neurofibrillary tangles in the cerebral cortex is used a pathological marker for a disease state and presents the major criterion for the diagnosis of Alzheimer’s disease at autopsy.
Alternate names: Amyloid beta peptide
Research Area Neurology, Alzheimer's Disease
Application Notes Immunohistochemistry: dilute 1: 50-1: 100 in an ABC method (incubation time 30 minutes atroom temperature). Suitable for formalin/paraffin tissues and frozen tissues. We suggest an incubation period of 30 minutes at room temperature. Recommended positive control: Brain. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Weidemann, Koenig, Bunke et al.: "Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein." in: Cell, Vol. 57, Issue 1, pp. 115-26, 1989 (PubMed).

Kang, Lemaire, Unterbeck et al.: "The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor." in: Nature, Vol. 325, Issue 6106, pp. 733-6, 1987 (PubMed).

Tanzi, McClatchey, Lamperti et al.: "Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease." in: Nature, Vol. 331, Issue 6156, pp. 528-30, 1988 (PubMed).

Alternatives for antigen "Amyloid beta (Abeta)", type "Antibodies"
Hosts (137), (78), (3)
Reactivities (183), (37), (20), (2), (1), (1)
Applications (146), (141), (57), (50), (40), (38), (30), (10), (5), (4), (2), (1), (1), (1)
Conjugates (13), (3)
Epitopes (56), (41), (26), (15), (9), (6), (6), (5), (4), (4), (3), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)