Linker For Activation of T Cells (LAT) (C-Term) antibody

Details for Product No. ABIN115246
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(16), (15), (13), (9), (6), (5), (4), (4), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
(159), (73), (72), (1)
(116), (43), (5), (1)
Clonality (Clone)
Monoclonal ()
(4), (4), (4), (4), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (1)
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Frozen Paraffin-embedded Sections) (IHC (frpe)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(121), (65), (30), (25), (25), (15), (14), (8), (5), (2), (2), (1), (1), (1)
Pubmed 3 references available
Quantity 0.5 mL
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Catalog No. ABIN115246
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Immunogen Prokaryotic recombinant protein corresponding to a region of 120 amino acids with in the C- terminus of the LAT molecule.
Clone 03-08-14
Isotype IgG1
Specificity Reacts to Linker for Activation of T Cells (LAT)
Cellular Localization: Membrane
Purification Supernatant
Alternative Name LAT
Background Linker for activation of T cells (LAT) is an integral membrane protein (36 to 38 kD), which plays an important role in linking engagement of the TCR to the biochemical events of T cell activation. LAT antibody stains thymus and peripheral lymphoid tissues such as T cell areas in lymph nodes and spleen. LAT is expressed in T lymphocytes in interstitial spaces, platelets and megakaryocytes. LAT is not expressed in B cells, macrophages, plasma cells, monocytes, epithelial histiocytes and dendritic cells.Synonyms: 36 kDa Phospho-Tyrosine Adapter Protein, Linker For Activation of T-Cells Family Member 1, p36-38, pp36
Gene ID 27040
NCBI Accession NP_001014987
UniProt O43561
Research Area Signaling, Adaptive Immunity
Application Notes Immunohistochemistry on paraffin sections: diluted of 1: 25 to 1: 50 in an ABC method (60 minutes at room temperature)Recommended Positive Control: Tonsil
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer 10 mM citrate buffer, pH 6.0 - containing sodium azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
General Facchetti, Chan, Zhang et al.: "Linker for activation of T cells (LAT), a novel immunohistochemical marker for T cells, NK cells, mast cells, and megakaryocytes: evaluation in normal and pathological conditions." in: The American journal of pathology, Vol. 154, Issue 4, pp. 1037-46, 1999 (PubMed).

Zhang, Sloan-Lancaster, Kitchen et al.: "LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation." in: Cell, Vol. 92, Issue 1, pp. 83-92, 1998 (PubMed).

Fukazawa, Reedquist, Panchamoorthy et al.: "T cell activation-dependent association between the p85 subunit of the phosphatidylinositol 3-kinase and Grb2/phospholipase C-gamma 1-binding phosphotyrosyl protein pp36/38." in: The Journal of biological chemistry, Vol. 270, Issue 34, pp. 20177-82, 1995 (PubMed).

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