Caudal Type Homeobox 2 (CDX2) (N-Term) antibody

Details for Product No. ABIN115278
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Antigen
Synonyms CDX2, MGC130987, cdx3-like, CDX-3, CDX3, CDX-2, Cdx-2
Epitope
N-Term
(28), (16), (12), (8), (8), (6), (5), (3), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(135), (52), (51), (17), (13), (13), (13), (3), (1), (1)
Host
Mouse
(104), (24), (11)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(95), (62), (36), (22), (15), (11), (10), (9), (8), (5), (2), (1), (1)
Pubmed 3 references available
Quantity 0.5 mL
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Availability Will be delivered in 6 to 8 Business Days
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Catalog No. ABIN115278
308.00 $
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Immunogen Prokaryotic recombinant protein corresponding to the 180 amino acid N-terminal region of the human CDX2 molecule
Clone AMT28
Isotype IgG1
Specificity This antibody reacts with CDX2, which is expressed in the nuclei of epithelial cells throughout the intestine, from duodenum to rectum. The CDX2 protein is expressed in primary and metastatic colorectal carcinomas and has also been demonstrated in the intestinal metaplasia of the stomach and intestinal-type gastric cancer, while it is not expressed in the normal gastric mucosa. Studies have shown that CDX2 is superior marker compared to CK20. Cellular localization: nuclear.
Purification Supernatant
Alternative Name Cdx2
Background CDX2 is a caudal type homeobox gene that encodes an intestine-specific transcription factor that is expressed early in intestinal development and may be involved in the regulation of proliferation and differentiation of intestinal epithelial cells.
Alternate names: CDX-3, CDX3, Caudal-type homeobox protein 2, Homeobox protein CDX-2
Gene ID 1045
NCBI Accession NP_001256
UniProt Q99626
Application Notes Immunohistochemistry on formalin-fixed paraffin embedded sections: This antibody maybe diluted to a titer of 1: 25-1: 50 in an ABC method (60 minutes at room temperature). Formalin-fixed paraffin embedded tissues require high temperature antigen unmaskingwith 1 mM EDTA buffer, pH 8.0 prior to immunostaining. Recommended positive control: Colon cancer. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Supplier Images
anti-Caudal Type Homeobox 2 (CDX2) (N-Term) antibody Immunohistochemical staining of colon cancer using CDX2 antibody
General Silberg, Swain, Suh et al.: "Cdx1 and cdx2 expression during intestinal development." in: Gastroenterology, Vol. 119, Issue 4, pp. 961-71, 2000 (PubMed).

Hinoi, Tani, Lucas et al.: "Loss of CDX2 expression and microsatellite instability are prominent features of large cell minimally differentiated carcinomas of the colon." in: The American journal of pathology, Vol. 159, Issue 6, pp. 2239-48, 2001 (PubMed).

Bai, Yamamoto, Akiyama et al.: "Ectopic expression of homeodomain protein CDX2 in intestinal metaplasia and carcinomas of the stomach." in: Cancer letters, Vol. 176, Issue 1, pp. 47-55, 2002 (PubMed).

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