Membrane-Spanning 4-Domains, Subfamily A, Member 1 (MS4A1) antibody

Antigen: Membrane-Spanning 4-Domains, Subfamily A, Member 1 (MS4A1)

Synonyms: B1, S7, Bp35, CD20, MS4A2, LEU-16, MGC3969, Cd20, Ly-44, Ms4a2, AA960661, FcRB, Fce1b, Ms4a1, Fcer1b, Fcrbeta, FCIGA, MS4A1, bp35, cd20, ms4a2, leu-16, ms4a4c, cd20-like

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Conjugate: Un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Catalog no.: ABIN115350

Additional Information

Alternative name: CD20

UniProt: P11836

Immunogen: Synthetic peptide derived from C-terminus of human CD20 protein.

Cross-Reactivity: Human

Description: CD20 is a non glycosylated protein with a molecular weight of 35 or 37 kDa depending onthe degree of phosphorylation. Although not a member of the tetraspanin superfamily ofcell surface receptors, it crosses the cell membrane four times. The CD20 antigen ispresent on human pre B lymphocytes and on B lymphocytes at all stages of maturation,except on plasma cells. Low level expression of the CD20 antigen has been detected onnormal T lymphocytes. The CD20 molecule is involved in regulation of B cell differentiation,presumably via its reported function as a Ca++ channel subunit

Characteristics: Synonyms: MS4A1, Leu-16, Bp35, B-cell marker, B-lymphocyte antigen CD20, Membrane-spanning4-domains subfamily A member 1, B-lymphocyte surface antigen B1

Application Details

Application Notes: Immunohistochemistry on Formalin/Paraffin Tissues: Use a dilution of 1/25-1/50 in an ABCmethod (30 minutes at room temperature). Recommended positive control: Tonsil. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.

Purification: Purified

Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Research Area: Cancer, Hematopoietic Progenitors, Hematopoietic Stem Cells, Adaptive Immunity, CD Antigens, Surface Receptors of Immune Cells

Restrictions: For Research Use only

Images

Formalin fixed paraffin embedded human tonsil stained with CD20 antibody ABIN115350

Publications

Lew, Duli?, Reed: "Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast." in: Cell, Vol. 66, Issue 6, pp. 1197-206, 1991 (PubMed).

Koff, Cross, Fisher et al.: "Human cyclin E, a new cyclin that interacts with two members of the CDC2 gene family." in: Cell, Vol. 66, Issue 6, pp. 1217-28, 1991 (PubMed).