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|+1 404 474 4654|
|+1 888 205 9894 (TF)|
Proopiomelanocortin (POMC) antibody
|Synonyms||MSH, ACTH, pomc, SI:bZ36D5.1, SI:bZ36D5.4, si:bz36d5.2, POMC, LPH, NPP, POC, CLIP|
Human, Rat (Rattus)
Alternatives Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
|4 references available|
|Price||440.00 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 6 to 8 Business Days|
|Alternative name||Adrenocorticotropic Hormone (ACTH)|
|Immunogen||Synthetic Human ACTH 1-24.|
|Cross-Reactivity||Human, Rat (Rattus)|
|Description||ACTH occurs in cells of the anterior pituitary and in neurons in brain. It regulates thecorticosteroid production in the adrenal cortex. Beta endorphin and Met enkephalin areendogenous opiates. MSH (melanocyte stimulating hormone) increases the pigmentationof skin by increasing melanin production in melanocytes.|
|Characteristics||Synonyms: Corticotropin, Adrenocorticotropic hormone, ACTH|
|Application Notes||Immunohistochemistry on Formalin Fixed, Paraffin Embedded Tissue Sections: Use at1/50-1/250 dilution in an ABC method (30 minutes at RT). Recommended Positive Control: PituitaryOther applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.|
|Storage||Store the antibody undiluted at 2-8°C. Shelf life: one year from despatch.|
|Restrictions||For Research Use only|
Liu, Zou, Slaughter et al.: "DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis." in: Cell, Vol. 89, Issue 2, pp. 175-84, 1997 (PubMed).
Enari, Sakahira, Yokoyama et al.: "A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD." in: Nature, Vol. 391, Issue 6662, pp. 43-50, 1998 (PubMed).
Sakahira, Enari, Nagata: "Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis." in: Nature, Vol. 391, Issue 6662, pp. 96-9, 1998 (PubMed).
McCarty, Toh, Li: "Study of DFF45 in its role of chaperone and inhibitor: two independent inhibitory domains of DFF40 nuclease activity." in: Biochemical and biophysical research communications, Vol. 264, Issue 1, pp. 176-80, 1999 (PubMed).