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Proopiomelanocortin (POMC) antibody

Antigen

Proopiomelanocortin (POMC)
Synonyms MSH, ACTH, pomc, SI:bZ36D5.1, SI:bZ36D5.4, si:bz36d5.2, POMC, LPH, NPP, POC, CLIP
Clonality Polyclonal
Host
Alternatives

Rabbit
Reactivity
Alternatives

Human, Rat (Rattus)
Conjugate
Alternatives Un-conjugated
Application
Alternatives Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
4 references available
Catalog no. ABIN115356
Quantity
Price 440.00 $   Plus shipping costs $45.00
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Additional Information
Application Details Publications Alternatives Variants back to top

Alternative name Adrenocorticotropic Hormone (ACTH)
UniProt P01189
Immunogen Synthetic Human ACTH 1-24.
Cross-Reactivity Human, Rat (Rattus)
Description ACTH occurs in cells of the anterior pituitary and in neurons in brain. It regulates thecorticosteroid production in the adrenal cortex. Beta endorphin and Met enkephalin areendogenous opiates. MSH (melanocyte stimulating hormone) increases the pigmentationof skin by increasing melanin production in melanocytes.
Characteristics Synonyms: Corticotropin, Adrenocorticotropic hormone, ACTH

Application Details
Publications Alternatives Variants back to top

Application Notes Immunohistochemistry on Formalin Fixed, Paraffin Embedded Tissue Sections: Use at1/50-1/250 dilution in an ABC method (30 minutes at RT). Recommended Positive Control: PituitaryOther applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Purification Serum
Storage Store the antibody undiluted at 2-8°C. Shelf life: one year from despatch.
Research Area Hormones
Restrictions For Research Use only

Publications
Application Details Alternatives Variants back to top

Liu, Zou, Slaughter et al.: "DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis." in: Cell, Vol. 89, Issue 2, pp. 175-84, 1997 (PubMed).

Enari, Sakahira, Yokoyama et al.: "A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD." in: Nature, Vol. 391, Issue 6662, pp. 43-50, 1998 (PubMed).

Sakahira, Enari, Nagata: "Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis." in: Nature, Vol. 391, Issue 6662, pp. 96-9, 1998 (PubMed).

McCarty, Toh, Li: "Study of DFF45 in its role of chaperone and inhibitor: two independent inhibitory domains of DFF40 nuclease activity." in: Biochemical and biophysical research communications, Vol. 264, Issue 1, pp. 176-80, 1999 (PubMed).

Alternatives
Application Details Publications Variants back to top

Alternatives for antigen "Proopiomelanocortin (POMC)", type "Antibodies"
Hosts Rabbit (200), Mouse (57), Goat (8), Sheep (5)
Reactivities Human (223), Rat (Rattus) (136), Mouse (Murine) (123), Cow (Bovine) (60), Sheep (Ovine) (38), Pig (Porcine) (27), Dog (Canine) (19), Guinea Pig (18), Camel (1), General (1)
Applications Immunofluorescence (IF) (112), ELISA (87), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (73), Western Blotting (WB) (44), Immunohistochemistry (IHC) (41), Immunohistochemistry (Frozen Sections) (IHC (fro)) (24), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (20), Immunocytochemistry (ICC) (16), Immunohistochemistry (Fixed) (IHC (fx)) (15), Radioimmunoassay (RIA) (15), Immunoprecipitation (IP) (9), Immunoelectron Microscopy (IEM) (6), Dot Blot (Dot) (4), Cellular Assay (CA) (2), Immunoassay (IA) (2), Immunostaining (ISt) (2), Dot Blot (DB) (1)
Conjugates Biotin (9), FITC (9), Alexa Fluor 350 (6), Alexa Fluor 488 (6), Alexa Fluor 555 (6), Alexa Fluor 647 (6), Cy3 (6), Cy5 (6), Cy5.5 (6), Cy7 (6), Gold (6), HRP (6), PE (6), PE,Cy3 (5), PE,Cy5 (5), PE,Cy5.5 (5), PE,Cy7 (5), PE-Cy3 (1), PE-Cy5 (1), PE-Cy5.5 (1), PE-Cy7 (1)
Epitopes C-Term (30), N-Term (25), AA 1-39 (20), AA 18-39 (18), AA 1-24 (7), AA 7-23 (5), AA 1-27 (3), AA 22-39 (3), AA 27-52 (2), AA 27-235 (1), pSer168 (1)