Poly (ADP-Ribose) Polymerase 1 (PARP1) (N-Term) antibody

Details for Product No. ABIN115385
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Antigen
Synonyms
5830444G22Rik, AI893648, ARTD1, Adprp, Adprt1, C80510, PARP, PPOL, parp-1, sPARP-1, ADPRT, ADPRT 1, ADPRT1, PARP-1, pADPRT-1, Adprt, Parp-1, BEST:LD21673, CG17685, CG17696, CG17718, CG40411, D.PARP, D ... show more
5830444G22Rik, AI893648, ARTD1, Adprp, Adprt1, C80510, PARP, PPOL, parp-1, sPARP-1, ADPRT, ADPRT 1, ADPRT1, PARP-1, pADPRT-1, Adprt, Parp-1, BEST:LD21673, CG17685, CG17696, CG17718, CG40411, D.PARP, Dm.pARTa, Dmel\\CG40411, LD21673.3prime, PARP1, dPARP, parp, adprt1, padprt-1, ppol, ART7.1, ART1 show less
Epitope
N-Term
(24), (9), (4), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(141), (40), (37), (23), (13), (2), (2), (2), (2), (1), (1), (1)
Host
Rabbit
(143), (28), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(123), (46), (43), (31), (29), (23), (17), (16), (10), (9), (7), (2), (1), (1), (1), (1)
Pubmed 2 references available
Catalog no. ABIN115385
Quantity 0.5 mL
Price
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Immunogen A synthetic peptide from the N-terminal region of human PARP.
Specificity This antibody reacts with a 116 kD protein, known as PARP. Cellular Localization: Nuclear.
Purification Purified
Alternative Name PARP1
Background Proteolysis of PARP to its stable 85 kD fragment is an early marker of apoptosis and is mediated by Caspase (CPP32) protein. PARP uses nicotinamide adenine dinucleotide (oxidized form) as a substrate to catalyze the transfer of ADP-ribose to a variety of nuclear acceptors.
Alternate names: ADPRT, ADPRT 1, NAD(+) ADP-ribosyltransferase 1, PARP-1, PPOL, Poly [ADP-ribose] polymerase 1, Poly[ADP-ribose] synthetase 1
Gene ID 142
NCBI Accession NP_001609.2
UniProt P09874
Application Notes Western Blot. Immunohistochemistry on Paraffin Embedded Sections: Use at 1/25-1/50 dilution in anABC method for 30 minutes at room temperature. High temperature treatment offormalin-fixed tissue sections with 10mM citrate buffer, pH 6.0 must be performed prior tothe immunostaining. Recommended Positive Control: Tonsil. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8°C.
Expiry Date 12 months
General Lamarre, Talbot, de Murcia et al.: "Structural and functional analysis of poly(ADP ribose) polymerase: an immunological study." in: Biochimica et biophysica acta, Vol. 950, Issue 2, pp. 147-60, 1988 (PubMed).

Tewari, Quan, ORourke et al.: "Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase." in: Cell, Vol. 81, Issue 5, pp. 801-9, 1995 (PubMed).

Hosts (143), (28), (1)
Reactivities (141), (40), (37), (23), (13), (2), (2), (2), (2), (1), (1), (1)
Applications (123), (46), (43), (31), (29), (23), (17), (16), (10), (9), (7), (2), (1), (1), (1), (1)
Conjugates (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (24), (9), (4), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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