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Baculoviral IAP Repeat-Containing 5 (BIRC5) (C-Term) antibody

Details for Product No. ABIN115387, Supplier: Log in to see
Antigen
  • API4
  • EPR-1
  • AAC-11
  • Api4
  • TIAP
  • survivin40
  • AP14
Alternatives
anti-Human Baculoviral IAP Repeat-Containing 5 antibody for Immunohistochemistry (Paraffin-embedded Sections)
Epitope
C-Term
20
5
4
4
3
3
2
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine)
65
34
10
1
1
1
Host
Rabbit
57
22
3
Clonality
Polyclonal
Conjugate
Un-conjugated
2
2
2
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
60
25
20
13
13
7
6
3
2
2
1
1
1
Supplier
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Immunogen A synthetic peptide derived from the C-terminal region of Survivin.
Specificity This antibody reacts with a 16.5 kDa protein, known as Survivin.
Cellular Localization: Cytoplasmic
Purification Purified
Alternative Name IAP4 / BIRC5 (BIRC5 Antibody Abstract)
Background Survivin is an inhibitor of apoptosis protein. It is expressed in the G2/M phase of the cell cycle in a cycle-regulated manner. At the beginning of mitosis, survivin associates with microtubules of the mitotic spindle. Disruption of survivin-microtubule interactions results in loss of survivins antiapoptosis function and increased Caspase-3 activity.Synonyms: API4, Apoptosis inhibitor 4, Apoptosis inhibitor survivin, Baculoviral IAP repeat-containing protein 5, Survivin
Gene ID 332
NCBI Accession NP_001012270
UniProt O15392
Research Area Cancer, Apoptosis/Necrosis, Neurology
Pathways Apoptosis, Cell Division Cycle
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Buffer 10 mM citrate buffer, pH 6.0, Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Background publications Li, Ambrosini, Chu et al.: "Control of apoptosis and mitotic spindle checkpoint by survivin." in: Nature, Vol. 396, Issue 6711, pp. 580-4, 1999 (PubMed).

Lu, Altieri, Tanigawa: "Expression of a novel antiapoptosis gene, survivin, correlated with tumor cell apoptosis and p53 accumulation in gastric carcinomas." in: Cancer research, Vol. 58, Issue 9, pp. 1808-12, 1998 (PubMed).

Ambrosini, Adida, Altieri: "A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma." in: Nature medicine, Vol. 3, Issue 8, pp. 917-21, 1997 (PubMed).